Evidence map›Paper›PMID 39356827›Full record

ArticleACS nano2024

Granular Porous Nanofibrous Microspheres Enhance Cellular Infiltration for Diabetic Wound Healing.

Meenakshi Kamaraj, Nafiseh Moghimi, Alec McCarthy, Junjie Chen, Selena Cao, Abdul Rahim Chethikkattuveli Salih, Akshat Joshi, Vadim Jucaud, Adriana Panayi, Su Ryon Shin and 4 more

Abstract read
In one paragraph

Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Meenakshi KamarajTerasaki Institute for Biomedical Innovations, Los Angeles, California 91367, United States.
Nafiseh MoghimiTerasaki Institute for Biomedical Innovations, Los Angeles, California 91367, United States.
Alec McCarthyDepartment of Surgery-Transplant and Mary & Dick Holland, Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Junjie ChenTerasaki Institute for Biomedical Innovations, Los Angeles, California 91367, United States.
Selena CaoTerasaki Institute for Biomedical Innovations, Los Angeles, California 91367, United States.
Abdul Rahim Chethikkattuveli SalihTerasaki Institute for Biomedical Innovations, Los Angeles, California 91367, United States.
Akshat JoshiTerasaki Institute for Biomedical Innovations, Los Angeles, California 91367, United States.
Vadim JucaudTerasaki Institute for Biomedical Innovations, Los Angeles, California 91367, United States.
Adriana PanayiDepartment of Hand-, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Heidelberg 69117, Germany.
Su Ryon ShinDivision of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Cambridge, Massachusetts 02139, United States.ORCID 0000-0003-0864-6482
Iman NoshadiDepartment of Bioengineering, University of California, Riverside, California 92521, United States.
Ali KhademhosseiniTerasaki Institute for Biomedical Innovations, Los Angeles, California 91367, United States.
Jingwei XieDepartment of Surgery-Transplant and Mary & Dick Holland, Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.ORCID 0000-0002-8126-1397
Johnson V JohnTerasaki Institute for Biomedical Innovations, Los Angeles, California 91367, United States.ORCID 0000-0001-8105-0808

Funding

Engineering the open porous nanofibrous microsphere integrated fibrillar hydrogel for the co-delivery of antibacterial and angiogenic agents aimed at the rapid diabetic wound repairR01DK134903 · NIDDK · TERASAKI INSTITUTE FOR BIOMEDICAL INNOVATION · PI Johnson Vitharikunnil John · 2023 to 2026
$2.2M
NIDDK NIH HHS R01 DK134903
6 · The paper itself

Abstract

Diabetic foot ulcers (DFUs) are a significant challenge in the clinical care of diabetic patients, often necessitating limb amputation and compromising the quality of life and life expectancy of this cohort. Minimally invasive therapies, such as modular scaffolds, are at the forefront of current DFU treatment, offering an efficient approach for administering therapeutics that accelerate tissue repair and regeneration. In this study, we report a facile method for fabricating granular nanofibrous microspheres (NMs) with predesigned structures and porosities. The proposed technology combines electrospinning and electrospraying to develop a therapeutic option for DFUs. Specifically, porous NMs were constructed using electrospun poly(lactic-

Indexed as

MicrospheresNanofibersWound HealingAnimalsDiabetes Mellitus, ExperimentalDiabetic FootFibroblastsHumansMicePolylactic Acid-Polyglycolic Acid CopolymerPorosityTissue ScaffoldsPolylactic Acid-Polyglycolic Acid Copolymercell carrierscell migrationcoaxial electrospraydiabetic wound repairnanofibrous microsphereporosity

Identifiers

PMID39356827
PMCPMC12121725

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.