Evidence map›Paper›PMID 39356763›Full record

ArticleScience advances2024

Orbit symmetry breaking in MXene implements enhanced soft bioelectronic implants.

Yizhang Wu, Yuan Li, Yihan Liu, Dashuai Zhu, Sicheng Xing, Noah Lambert, Hannah Weisbecker, Siyuan Liu, Brayden Davis, Lin Zhang and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Delaying Drug Release: A Time Capsule for the Heart.JACC. Basic to translational science · 2025
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Yizhang WuDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0001-6244-8458
Yuan LiDepartment of Biomedical Engineering, Columbia University, NY, New York 10032, USA.ORCID 0000-0002-1929-5465
Yihan LiuDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0003-3671-9191
Dashuai ZhuDepartment of Biomedical Engineering, Columbia University, NY, New York 10032, USA.ORCID 0000-0002-4645-5786
Sicheng XingDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0009-0004-8227-2217
Noah LambertDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Hannah WeisbeckerDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0002-3893-4891
Siyuan LiuDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Brayden DavisDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0009-0002-8155-7152
Lin ZhangDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0001-9744-8503
Meixiang WangDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27606, USA.ORCID 0000-0001-8441-2288
Gongkai YuanDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Chris Zhoufan YouChapel Hill High School, Chapel Hill, NC 27516, USA.ORCID 0009-0005-2343-8149
Anran ZhangDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0009-0008-8442-2695
Cate DuncanDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0009-0009-3872-6150
Wanrong XieDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0009-0001-5872-1228
Yihang WangDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0002-8903-4279
Yong WangSchool of Physics, Nanjing University, Nanjing 210093, China.
Sreya KanamurlapudiJoint Department of Biomedical Engineering, North Carolina State University and University of North Carolina at Chapel Hill, Raleigh, NC 27607, USA.
Garcia-Guzman EvertDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Arjun PutchaDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0001-9834-3754
Michael D DickeyDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27606, USA.ORCID 0000-0003-1251-1871
Ke HuangDepartment of Biomedical Engineering, Columbia University, NY, New York 10032, USA.ORCID 0000-0002-9355-7224
Wubin BaiDepartment of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID 0000-0003-2872-5559

Funding

Wearable, Wireless Deep-tissue Sensing Patch for Continuous Monitoring of Recovery from Microsurgical Tissue TransferR01EB034332 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wubin Bai · 2023 to 2026
$1.3M
NIBIB NIH HHS R01 EB034332
6 · The paper itself

Abstract

Bioelectronic implants featuring soft mechanics, excellent biocompatibility, and outstanding electrical performance hold promising potential to revolutionize implantable technology. These biomedical implants can record electrophysiological signals and execute direct therapeutic interventions within internal organs, offering transformative potential in the diagnosis, monitoring, and treatment of various pathological conditions. However, challenges remain in improving excessive impedance at the bioelectronic-tissue interface and thus the efficacy of electrophysiological signaling and intervention. Here, we devise orbit symmetry breaking in MXene (a low-cost scalability, biocompatible, and conductive two dimensionally layered material, which we refer to as OBXene), which exhibits low bioelectronic-tissue impedance, originating from the out-of-plane charge transfer. Furthermore, the Schottky-induced piezoelectricity stemming from the asymmetric orbital configuration of OBXene facilitates interlayered charge transport in the device. We report an OBXene-based cardiac patch applied on the left ventricular epicardium of both rodent and porcine models to enable spatiotemporal epicardium mapping and pacing while coupling the wireless and battery-free operation for long-term real-time recording and closed-loop stimulation.

Indexed as

Prostheses and ImplantsAnimalsBiocompatible MaterialsElectric ImpedanceOrbitSwineBiocompatible Materials

Identifiers

PMID39356763
PMCPMC11446273

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.