Evidence map›Paper›PMID 39356761›Full record

ArticleScience advances2024

Single-molecule tracking reveals dynamic regulation of ribosomal scanning.

Hea Jin Hong, Antonia L Zhang, Adam B Conn, Gregor Blaha, Seán E O'Leary

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Dynamics and Regulation of mRNA Cap Recognition by Human eIF4F.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hea Jin HongDepartment of Biochemistry, University of California Riverside, Riverside, CA 92521, USA.ORCID 0009-0002-7957-8237
Antonia L ZhangDepartment of Biochemistry, University of California Riverside, Riverside, CA 92521, USA.
Adam B ConnDepartment of Biochemistry, University of California Riverside, Riverside, CA 92521, USA.ORCID 0009-0004-6471-7307
Gregor BlahaDepartment of Biochemistry, University of California Riverside, Riverside, CA 92521, USA.ORCID 0000-0001-7228-0185
Seán E O'LearyDepartment of Biochemistry, University of California Riverside, Riverside, CA 92521, USA.ORCID 0000-0002-1214-949X

Funding

Dynamics of Eukaryotic Ribosomal ScanningR01GM138939 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Sean E O'Leary · 2020 to 2026
$2.0M
NIGMS NIH HHS R00 GM111898NIGMS NIH HHS R01 GM138939
6 · The paper itself

Abstract

How eukaryotic ribosomes traverse messenger RNA (mRNA) leader sequences to search for protein-synthesis start sites remains one of the most mysterious aspects of translation and its regulation. While the search process is conventionally described by a linear "scanning" model, its exquisitely dynamic nature has restricted detailed mechanistic study. Here, we observed single

Indexed as

RibosomesRNA, MessengerSaccharomyces cerevisiaeGuanosine TriphosphateProtein BiosynthesisSaccharomyces cerevisiae ProteinsSingle Molecule ImagingGuanosine TriphosphateRNA, MessengerSaccharomyces cerevisiae Proteins

Identifiers

PMID39356761
PMCPMC11446271

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.