Evidence map›Paper›PMID 39356708›Full record

ArticlePloS one2024

Younger and rural children are more likely to be hospitalized for SARS-CoV-2 infections.

Rebecca M Cantu, Sara C Sanders, Grace A Turner, Jessica N Snowden, Ashton Ingold, Susanna Hartzell, Suzanne House, Dana Frederick, Uday K Chalwadi, Eric R Siegel and 1 more

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Rebecca M CantuDivision of Hospital Medicine, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Sara C SandersDivision of Hospital Medicine, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Grace A TurnerArkansas Children's Research Institute, Little Rock, Arkansas, United States of America.
Jessica N SnowdenArkansas Children's Hospital, Little Rock, Arkansas, United States of America.
Ashton IngoldArkansas Children's Research Institute, Little Rock, Arkansas, United States of America.
Susanna HartzellArkansas Children's Research Institute, Little Rock, Arkansas, United States of America.
Suzanne HouseArkansas Children's Research Institute, Little Rock, Arkansas, United States of America.
Dana FrederickArkansas Children's Research Institute, Little Rock, Arkansas, United States of America.
Uday K ChalwadiDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Eric R SiegelDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
Joshua L KennedyArkansas Children's Hospital, Little Rock, Arkansas, United States of America.ORCID 0000-0002-1919-9051

Funding

Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Alan Tackett, Sean D. Taverna · 2017 to 2026
$27.6M
Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6M
NCATS NIH HHS UL1 TR003107NIGMS NIH HHS P20 GM121293
6 · The paper itself

Abstract

purposeTo identify characteristics of SARS-CoV-2 infection that are associated with hospitalization in children initially evaluated in a Pediatric Emergency Department (ED).

methodsWe identified cases of SARS-CoV-2 positive patients seen in the Arkansas Children's Hospital (ACH) ED or hospitalized between May 27, 2020, and April 28, 2022, using ICD-10 codes within the Pediatric Hospital Information System (PHIS) Database. We compared infection waves for differences in patient characteristics and used logistic regressions to examine which features led to a higher chance of hospitalization.

findingsWe included 681 pre-Delta cases, 673 Delta cases, and 970 Omicron cases. Almost 17% of patients were admitted to the hospital. Compared to Omicron-infected children, pre-Delta and Delta-infected children were twice as likely hospitalized (OR = 2.2 and 2.0, respectively; p<0.0001). Infants under one year were >3 times as likely to be hospitalized than children ages 5-14 years regardless of wave (OR = 3.42; 95%CI = 2.36-4.94). Rural children were almost three times as likely than urban children to be hospitalized across all waves (OR = 2.73; 95%CI = 1.97-3.78). Finally, those with a complex condition had nearly a 15-fold increase in odds of admission (OR = 14.6; 95%CI = 10.6-20.0).

conclusionsChildren diagnosed during the pre-Delta or Delta waves were more likely to be hospitalized than those diagnosed during the Omicron wave. Younger and rural patients were more likely to be hospitalized regardless of the wave. We suspect lower vaccination rates and larger distances from medical care influenced higher hospitalization rates.

Indexed as

COVID-19HospitalizationRural PopulationSARS-CoV-2AdolescentAge FactorsArkansasChildChild, PreschoolEmergency Service, HospitalFemaleHumansInfantInfant, NewbornMale

Identifiers

PMID39356708
PMCPMC11446435

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.