Evidence map›Paper›PMID 39356624›Full record

ReviewCancer research2024

Impact of Structural Racism and Social Determinants of Health on Disparities in Breast Cancer Mortality.

Mary Falcone, Bodour Salhia, Chanita Hughes Halbert, Evanthia T Roussos Torres, Daphne Stewart, Mariana C Stern, Caryn Lerman

Abstract readReview
In one paragraph

Review in Cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mary FalconeUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-8451-2438
Bodour SalhiaUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0003-3843-3621
Chanita Hughes HalbertUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-0103-6916
Evanthia T Roussos TorresUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-0740-5102
Daphne StewartUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0001-9845-8375
Mariana C SternUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0001-9777-4683
Caryn LermanUSC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-7553-8724

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VERONICA WENDY SETIAWAN · 1985 to 2026
$181.4M
NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

The striking ethnic and racial disparities in breast cancer mortality are not explained fully by pathologic or clinical features. Structural racism contributes to adverse conditions that promote cancer inequities, but the pathways by which this occurs are not fully understood. Social determinants of health, such as economic status and access to care, account for a portion of this variability, yet interventions designed to mitigate these barriers have not consistently led to improved outcomes. Based on the current evidence from multiple disciplines, we describe a conceptual model in which structural racism and racial discrimination contribute to increased mortality risk in diverse groups of patients by promoting adverse social determinants of health that elevate exposure to environmental hazards and stress; these exposures in turn contribute to epigenetic and immune dysregulation, thereby altering breast cancer outcomes. Based on this model, opportunities and challenges arise for interventions to reduce racial and ethnic disparities in breast cancer mortality.

Indexed as

Breast NeoplasmsHealth Status DisparitiesRacismSocial Determinants of HealthFemaleHealthcare DisparitiesHumans

Identifiers

PMID39356624
PMCPMC11611670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.