Evidence map›Paper›PMID 39356621›Full record

Observational studyJournal of addiction medicine

Readmissions Among Patients With Surgically Managed Drug Use Associated-Infective Endocarditis Before and After the Implementation of an Addiction Consult Team: A Retrospective, Observational Analysis.

Lucas X Marinacci, Audrey Li, Annie Tsay, Yoel Benarroch, Kevin P Hill, Adolf W Karchmer, Rishi K Wadhera, Katherine Kentoffio

Abstract readObservational Study
In one paragraph

Observational study in Journal of addiction medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lucas X MarinacciFrom the Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (LXM, RKW, KK); Harvard Medical School, Boston, MA (LXM, YB, KPH, AWK, RKW, KK); Center for Infectious Diseases, Boston Medical Center, Boston, MA (AL); Boston University Chobanian & Avedisian School of Medicine, Boston, MA (AL); Cardiology Service at Memorial Sloan Kettering Cancer Center, New York, NY (AT); Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (YB); Division of Addiction Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA (KPH); and Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA (AWK).ORCID 0000-0002-4443-2441
Audrey Li
Annie Tsay
Yoel Benarroch
Kevin P Hill
Adolf W Karchmer
Rishi K Wadhera
Katherine Kentoffio

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Clinical Addiction Research and Education ProgramR25DA013582 · NIDA · BOSTON MEDICAL CENTER · PI JEFFREY H. SAMET, Alexander Yale Walley · 2001 to 2026
$8.9M
Training Program in Cardiovascular ResearchT32HL160522 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Jennifer E Ho · 2022 to 2026
$2.7M
NCI NIH HHS P30 CA008748NHLBI NIH HHS T32 HL160522NIDA NIH HHS R25 DA013582
6 · The paper itself

Abstract

backgroundPatients who undergo cardiac surgery for drug use-associated infective endocarditis (DUA-IE) have high rates of readmissions for recurrent endocarditis, substance use disorder (SUD), and septicemia. Our primary objective was to assess whether exposure to an addiction consult team (ACT) was associated with reduced readmissions in this population.

methodsThis single-center retrospective analysis identified patients who underwent cardiac surgery for DUA-IE between 1/2012-9/2022 using the Society for Thoracic Surgeons database, and compared the cumulative incidence of readmissions at 1, 3, 6, and 12 months among those cared for before and after the implementation of an ACT in 9/2017, accounting for competing risk of mortality and adjusted for measured confounders using inverse probability of treatment weighting.

resultsThe 58 patients (35 pre-ACT and 23 post-ACT) were young (36.4 +/- 7.7 years) and predominantly White (53.4%) and male (70.7%). The post-ACT cohort had a significantly lower risk of readmission at 1 month (adjusted risk difference [RD] -23.8% [95% CI -94.4%, -8.3%], P = 0.005) and 3 months (RD -34.1% [-55.1%, -13.1%], P = 0.005), but not at 6 or 12 months. In a sensitivity analysis, the post-ACT cohort also had significantly lower risk of readmissions for SUD complications at 3 months. DISCUSSION AND

conclusionACT exposure was associated with a lower risk of short-term readmission among patients with surgically managed DUA-IE, possibly due to a reduction in SUD-related complications. Additional studies are needed to replicate these findings and to identify ways to sustain the potential benefits of ACTs over the longer term.

Indexed as

EndocarditisPatient ReadmissionSubstance-Related DisordersAdultCardiac Surgical ProceduresFemaleHumansMaleMiddle AgedReferral and ConsultationRetrospective Studies

Identifiers

PMID39356621
PMCPMC11449258

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.