Evidence map›Paper›PMID 39356382›Full record

ArticleMarine biotechnology (New York, N.Y.)2024

Epidermal distribution of tetrodotoxin-rich cells in newly hatched larvae of Takifugu spp.

Keishiro Inahashi, Ryo Yonezawa, Kentaro Hayashi, Soichi Watanabe, Kazutoshi Yoshitake, Ashley Rinka Smith, Yui Kaneko, Inori Watanabe, Rei Suo, Shigeharu Kinoshita and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Keishiro InahashiGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, 113-8657, Japan.
Ryo YonezawaGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, 113-8657, Japan.
Kentaro HayashiGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, 113-8657, Japan.
Soichi WatanabeGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, 113-8657, Japan.
Kazutoshi YoshitakeGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, 113-8657, Japan.
Ashley Rinka SmithGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, 113-8657, Japan.
Yui KanekoCollege of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan.
Inori WatanabeCollege of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan.
Rei SuoCollege of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan.
Shigeharu KinoshitaGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, 113-8657, Japan.
Muhammad Ahya RafiuddinNoto Center for Fisheries Science and Technology, Kanazawa University, Ossaka, Noto-Cho, Ishikawa, 927-0552, Japan.
Yuki SekiNoto Center for Fisheries Science and Technology, Kanazawa University, Ossaka, Noto-Cho, Ishikawa, 927-0552, Japan.
Arata NagamiNoto Center for Fisheries Science and Technology, Kanazawa University, Ossaka, Noto-Cho, Ishikawa, 927-0552, Japan.
Hajime MatsubaraNoto Center for Fisheries Science and Technology, Kanazawa University, Ossaka, Noto-Cho, Ishikawa, 927-0552, Japan.
Nobuo SuzukiNoto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University, Ogi, Noto-Cho, Ishikawa, 927-0553, Japan.
Tomohiro TakataniGraduate School of Integrated Science and Technology, Nagasaki University, Nagasaki, 852-8521, Japan.
Osamu ArakawaGraduate School of Integrated Science and Technology, Nagasaki University, Nagasaki, 852-8521, Japan.
Miwa SuzukiCollege of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan.
Shuichi AsakawaGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo, 113-8657, Japan. asakawa@g.ecc.u-tokyo.ac.jp.
Shiro ItoiCollege of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan. sitoi@nihon-u.ac.jp.

Funding

Japan Science and Technology Agency JPMJSP2108Japan Society for the Promotion of Science 19H00954Japan Society for the Promotion of Science 22J10627Kanazawa University 22037Nihon University Research Grant 2023-2024
6 · The paper itself

Abstract

Pufferfish of the genus Takifugu possess tetrodotoxin (TTX), known as "pufferfish toxin" and it is believed that pufferfish eggs and newly hatched larvae utilize TTX as a defensive substance against predators. However, the mechanism for the placement of TTX to specific cells on the larval body surface during the developmental process remains unknown. In this study, we clarify the distribution and characteristics of TTX-rich cells. We performed whole-mount immunohistochemistry (IHC) using anti-TTX monoclonal antibody on larvae of two pufferfish species, Takifugu rubripes and Takifugu alboplumbeus, just after hatching. This allowed observation of the TTX location and compared it with those of wheat germ agglutinin (WGA)-positive (periodic acid-Schiff (PAS)-positive) cells for mucous cells and IHC using anti-Na

Indexed as

EpidermisLarvaTakifuguTetrodotoxinAnimalsEpidermal CellsImmunohistochemistrySodium-Potassium-Exchanging ATPaseSodium-Potassium-Exchanging ATPaseTetrodotoxinEpidermisFish larvaeImmunohistochemistryPufferfishTakifuguTetrodotoxin (TTX)

Identifiers

PMID39356382
PMCPMC11541287

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.