Evidence map›Paper›PMID 39356158›Full record

ArticleInfection and immunity2024

Molecular mechanisms of

A P Fratzke, J A Szule, S M Butler, E J van Schaik, J E Samuel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

A P FratzkeDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
J A SzuleDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
S M ButlerDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, Texas, USA.
E J van SchaikDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, Texas, USA.
J E SamuelDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.ORCID 0000-0002-3896-8581

Funding

Comparative Biomedical Research Training for VeterinariansT32OD011083 · OD · TEXAS A&M AGRILIFE RESEARCH · PI ALBERT MULENGA · 2012 to 2026
$4.8M
Identification and Role of Type IV Secretion Effector Proteins in Coxiella burnetiiR01AI090142 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SAMUEL, JAMES EVANS · 2012 to 2024
$3.4M
VACCINE INTERVENTION AGAINST Q FEVERR01AI048829 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SAMUEL, JAMES E · 2000 to 2003
$1.1M
NIAID NIH HHS R01 AI048829NIAID NIH HHS R01 AI090142NIH HHS T32 OD011083
6 · The paper itself

Abstract

Local and systemic reactogenic responses to Q-VAX have prevented licensing of this vaccine outside of Australia. These reactogenic responses occur in previously sensitized individuals and have not been well defined at the cellular level, in part because many studies have been done in guinea pigs that have limited molecular tools. We previously characterized a mouse model of reactogenicity where local reaction sites showed an influx of CD8+ and IFNγ-expressing IL17a+ CD4+ T cells consistent with a Th1 delayed-type hypersensitivity. In this study, we determined, using depletion and adoptive transfer experiments, that both anti-

Indexed as

Bacterial VaccinesCD4-Positive T-LymphocytesCoxiella burnetiiAdoptive TransferAnimalsAntibodies, BacterialCD8-Positive T-LymphocytesFemaleFormaldehydeInterferon-gammaMiceMice, Inbred C57BLQ FeverVaccinationAntibodies, BacterialBacterial VaccinesFormaldehydeInterferon-gammaanimal modelimmune correlatesQ fevervaccine

Identifiers

PMID39356158
PMCPMC11556133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.