Evidence map›Paper›PMID 39355904›Full record

ArticleCirculation. Genomic and precision medicine2024

Common

Nana Liu, Jeffrey Hsu, Gautam Mahajan, Han Sun, Kenneth R Laurita, Sathyamangla V Naga Prasad, John Barnard, David R Van Wagoner, Chandrasekhar R Kothapalli, Mina K Chung and 1 more

Abstract read
In one paragraph

Article in Circulation. Genomic and precision medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nana LiuDepartments of Cardiovascular and Metabolic Sciences, Cardiovascular Medicine, OH (N.L., J.H., S.V.N.P., D.R.V.W., M.K.C., J.D.S.).ORCID 0000-0002-5010-599X
Jeffrey HsuDepartments of Cardiovascular and Metabolic Sciences, Cardiovascular Medicine, OH (N.L., J.H., S.V.N.P., D.R.V.W., M.K.C., J.D.S.).ORCID 0000-0002-9992-4515
Gautam MahajanDepartment of Chemical and Biomedical Engineering, Cleveland State University, OH (G.M., C.R.K.).ORCID 0000-0001-9892-0996
Han SunDepartment of Quantitative Health Sciences (H.S., J.B.).ORCID 0000-0001-9164-5282
Kenneth R LauritaDepartment of Medicine and Biomedical Engineering, Metrohealth Campus, OH (K.R.L.).ORCID 0000-0002-6341-9656
Sathyamangla V Naga PrasadDepartments of Cardiovascular and Metabolic Sciences, Cardiovascular Medicine, OH (N.L., J.H., S.V.N.P., D.R.V.W., M.K.C., J.D.S.).ORCID 0000-0003-3984-3788
John BarnardDepartment of Quantitative Health Sciences (H.S., J.B.).ORCID 0000-0003-2403-8268
David R Van WagonerDepartments of Cardiovascular and Metabolic Sciences, Cardiovascular Medicine, OH (N.L., J.H., S.V.N.P., D.R.V.W., M.K.C., J.D.S.).ORCID 0000-0001-8250-9828
Chandrasekhar R KothapalliDepartment of Chemical and Biomedical Engineering, Cleveland State University, OH (G.M., C.R.K.).ORCID 0000-0001-8450-0640
Mina K ChungDepartments of Cardiovascular and Metabolic Sciences, Cardiovascular Medicine, OH (N.L., J.H., S.V.N.P., D.R.V.W., M.K.C., J.D.S.).ORCID 0000-0002-7835-6045
Jonathan D SmithDepartments of Cardiovascular and Metabolic Sciences, Cardiovascular Medicine, OH (N.L., J.H., S.V.N.P., D.R.V.W., M.K.C., J.D.S.).ORCID 0000-0002-0415-386X

Funding

IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Project 3 Genes to Omics-Informed Drugs: Drug Repositioning and Testing to Prevent AF ProgressionsP01HL158502 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Mina Kay Chung · 2022 to 2026
$16.9M
Functional Genomics of Atrial Fibrillation in Human AtriaR01HL111314 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BARNARD, JOHN, CHUNG, MINA KAY · 2012 to 2019
$6.1M
American Heart Association-American Stroke Association 18SFRN34110067NHLBI NIH HHS P01 HL158502NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL111314
6 · The paper itself

Abstract

backgroundAtrial fibrillation GWAS (genome-wide association studies) identified significant associations for rs1152591 and linked variants in the

methodsReporter gene vector transfection and CRISPR-Cas9 editing were used to identify the causal variant regulating the expression of

resultsThe risk allele of rs1152591 had lower promoter and enhancer activity and was significantly associated with lower expression of the short

conclusionsrs1152591 was identified as a causal atrial fibrillation variant, with the risk allele decreasing

Indexed as

Atrial FibrillationMyocytes, CardiacNerve Tissue ProteinsAllelesCell NucleusCytoskeletal ProteinsGenome-Wide Association StudyHumansMicrofilament ProteinsNuclear ProteinsPolymorphism, Single NucleotideCytoskeletal ProteinsMicrofilament ProteinsNerve Tissue ProteinsNuclear ProteinsSYNE2 protein, humanatrial fibrillationelectrophysiologynuclear envelopestaining and labelingtransfection

Identifiers

PMID39355904
PMCPMC11522946

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.