Evidence map›Paper›PMID 39355652›Full record

ArticleInternational journal of nanomedicine2024

Chimeric Antigen-LgDNA Nanoparticles Attenuate Airway Th2 Polarization.

Ruien Chen, Huamei Zou, Xiuwen Ye, Bailing Xie, Aizhi Zhang, Lihua Mo, Yu Liu, Huanping Zhang, Gui Yang, Pingchang Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruien Chen *Department of Otolaryngology, Longgang Central Hospital and Guangzhou University of Chinese Traditional Medicine Shenzhen Clinical College, Shenzhen, 518116, People's Republic of China.
Huamei Zou *Department of Otolaryngology, Longgang Central Hospital and Guangzhou University of Chinese Traditional Medicine Shenzhen Clinical College, Shenzhen, 518116, People's Republic of China.
Xiuwen Ye *Department of Otolaryngology, Longgang Central Hospital and Guangzhou University of Chinese Traditional Medicine Shenzhen Clinical College, Shenzhen, 518116, People's Republic of China.
Bailing XieState Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University and Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, 518055, People's Republic of China.
Aizhi ZhangDepartment of Critical Care Medicine, Second Hospital, Shanxi Medical University, Taiyuan, 030001, People's Republic of China.
Lihua MoDepartment of General Medicine Practice, Third Affiliated Hospital, Shenzhen University, Shenzhen, 518005, People's Republic of China.
Yu LiuDepartment of General Medicine Practice, Third Affiliated Hospital, Shenzhen University, Shenzhen, 518005, People's Republic of China.
Huanping ZhangDepartment of Allergy Medicine, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030001, People's Republic of China.
Gui YangDepartment of Otolaryngology, Longgang Central Hospital and Guangzhou University of Chinese Traditional Medicine Shenzhen Clinical College, Shenzhen, 518116, People's Republic of China.
Pingchang YangState Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University and Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, 518055, People's Republic of China.ORCID 0000-0002-6806-9464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The therapeutic efficacy for airway allergies needs to be improved. Th2 polarization is a primary pathological feature of airway allergies. We constructed chimeric antigen-LgDNA ( Methods: In this study, disulfide bond-linked antigen-major histocompatibility complex II (MHC II)-LgDNA nanoparticles (NPs) were constructed and designated CAP-NPs. An airway Th2 polarization mouse model was established to test the effects of CAP-NPs on suppressing the Th2 response. Results: The CAP-NP components of ovalbumin (OVA), major histocompatibility complex II (MHC II), and LgDNA were confirmed in a series of laboratory tests. The CAP-NPs remained stable at pH7.2 for at least 96 h. In in vitro experiments, CAP-NPs bound to the surface of OVA-specific CD4 Discussion: In this paper, we constructed CAP-NPs that could induce antigen-specific CD4

Indexed as

ApoptosisNanoparticlesOvalbuminTh2 CellsAnimalsAntigensCaspase 8CD4-Positive T-LymphocytesDNAFemaleMiceMice, Inbred BALB CAntigensCaspase 8DNAOvalbuminairway allergynanoparticleT celltherapyvaccine

Identifiers

PMID39355652
PMCPMC11444059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.