ArticleCureus2024
Histological Changes in Ruptured Anterior Cruciate Ligament: A Comparative, Prospective, Observational Study in Different Age Groups and Time of Presentation Since Injury.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Histological and Immunohistochemical Characterization of the Tibial ACL Remnant: Implications for Ligament Healing.Medicina (Kaunas, Lithuania) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anterior cruciate ligament (ACL) injury is one of the most common sports-related injuries. Because of its intra-capsular location, it has very little chance of healing following injury. The causes of poor healing of ACL tears are mostly due to poor vascularity, disorganized collagen bundles, insufficient myofibroblast proliferation, etc. The healing potential is also varied in different age groups like any other tissue. Here, we studied the histological changes in ACL remnants that occur after ACL injury in different age groups and with varied times of presentation since injury. It was a prospective observational study comparing the histopathology of ACL remnants in 12 subgroups of cases. Healthy synovial lining, presence of inflammatory cells, neo-vascularization, and myofibroblasts are needed for natural healing of ACL. We found a favorable environment for the healing of ACL in younger patients with an injury period of one to three months. We suggest cases with a partial tear of ACL in a young individual presented within one to three months duration may be encouraged for conservative treatment or ACL repair surgery rather than ACL reconstruction. Our initial study on the histopathology of torn ACL has added insight into the existing literature and further studies are needed to substantiate its further application.
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Registered trials
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