Evidence map›Paper›PMID 39354827›Full record

ArticleRadiation oncology journal2024

Long-term treatment of metastatic adenoid cystic carcinoma with sequential brachytherapy and stereotactic body radiotherapy.

Allison Y Zhong, Sangwoo S Kim, Austin Hopper, Greg White, Sayuri Miyauchi, Riley N Jones, Dan Scanderbeg, Loren K Mell, Elizabeth Weihe, Nathalie Boutros and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiation oncology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Allison Y ZhongDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Sangwoo S KimDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Austin HopperDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Greg WhiteDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Sayuri MiyauchiDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Riley N JonesDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Dan ScanderbegDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Loren K MellDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Elizabeth WeiheDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Nathalie BoutrosDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Stephen W DoggettDepartment of Radiation Oncology, Providence Mission Hospital, Mission Viejo, CA, USA.
Andrew B SharabiDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.

Funding

University of California
6 · The paper itself

Abstract

Adenoid cystic carcinoma is a malignancy that is difficult to treat and often metastasizes to the lung. Systemic chemotherapies are not effective for this tumor type, thus local therapies are frequently used. Here, we report a case demonstrating the use of extensive ablative interventions in controlling the progression of metastatic adenoid cystic carcinoma. A patient with adenoid cystic carcinoma developed numerous metastases to his lungs and liver. Local ablative therapies including interstitial brachytherapy and SBRT were used to treat approximately 80 different metastases over the course of a decade. Over 850 brachytherapy seeds were implanted in this patient, and the tumor control and patient outcome were good. As of the most recent follow-up in March 2024, the patient has survived for approximately 12 years since his diagnosis of adenoid cystic carcinoma. To our knowledge, this case represents the most brachytherapy treatments reported in a single patient. It highlights the utility of interstitial brachytherapy and SBRT in treating extensive lung and liver metastases.

Indexed as

Adenoid cystic carcinomaBrachytherapyNeoplasm metastasisRadiationRadiotherapy

Identifiers

PMID39354827
PMCPMC11467482

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.