Evidence map›Paper›PMID 39354767›Full record

ArticleCurrent cancer drug targets2025

MMP7, Regulated by c-Jun, is Involved in Oral Squamous Cell Carcinoma and Associated with Cancer-Related Fibroblasts Infiltration.

Jian Wei, Xiaoxi Jiang, Yiwen Xu, Minhai Nie, Sen Yang, Xiao Chen, Lijuan Huang, Xuqian Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Current cancer drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jian WeiDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, 646000, P.R. China.
Xiaoxi JiangDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, 646000, P.R. China.
Yiwen XuDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, 646000, P.R. China.
Minhai NieDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, 646000, P.R. China.
Sen YangDepartment of Oral and Maxillofacial Surgery, Suining Central Hospital, Suining, 629000, P.R. China.
Xiao ChenDepartment of Oral Medical Technology, Sichuan College of Traditional Chinese Medicine, Mianyang, 621000, P.R. China.
Lijuan HuangDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, 646000, P.R. China.
Xuqian LiuDepartment of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, 646000, P.R. China.

Funding

National Key Laboratory of Oral Disease Prevention and Treatment of Open Subject Project SKLOD2024OF04National Natural Science Foundation of China 82401112XuYong People's Hospital-Southwest Medical University Joint Project 2024XYXNYD17
6 · The paper itself

Abstract

objectiveThis study aimed to analyze the expression of Matrix Metalloproteinase 7 (MMP7) and molecular mechanism at the Transcription Factor (TF) level in Oral Squamous Cell Carcinoma (OSCC).

methodsMMP7 expression was preliminarily explored in Head and Neck Squamous Cell Carcinoma (HNSCC) in the online database, followed by functional analysis and prediction of TF of MMP7. IHC was employed to detect MMP7 levels in OSCC samples. SCC9 and 293T cells were used to explore the transcriptional and regulatory effects of predicted TF on MMP7 by reporter double luciferase assay, RT-qPCR, western blotting, and cellular immunofluorescence. Transwell and TUNEL were employed to detect the migration and apoptosis.

resultsMMP7 was significantly up-regulated in HNSCC and OSCC tissues. Moreover, MMP7 was positively correlated with CAFs and significantly enriched in the signaling pathway of RNA degradation. The c-Jun pathway was also up-regulated in OSCC tissues, and predicted to be optimal TF of MMP7 with positive regulatory relationship. In OSCC, silencing and overexpression of c-Jun significantly decreased and increased the level of MMP7. Meanwhile, c- Jun affected the behavior of SCC9 cells, which showed that after c-Jun gene silencing, the ability of cell migration was weakened, while apoptosis was enhanced.When c-Jun gene was overexpressed, the migration ability was enhanced, but apoptosis was not significantly affected.

conclusionMMP7 has been proven to be a key protein in the development of OSCC, and has the potential to become a biological marker and therapeutic target. It has been found that c-Jun could bind to the MMP7 promoter region, and the silencing or overexpression of c-Jun can positively regulate the expression of MMP7.

Indexed as

Carcinoma, Squamous CellFibroblastsMatrix Metalloproteinase 7Mouth NeoplasmsProto-Oncogene Proteins c-junSquamous Cell Carcinoma of Head and NeckApoptosisCell Line, TumorCell MovementFemaleGene Expression Regulation, NeoplasticHumansMaleUp-RegulationMatrix Metalloproteinase 7MMP7 protein, humanProto-Oncogene Proteins c-junapoptosis.c-Junmatrix metalloproteinase 7Oral squamous cell carcinomatherapeutic targettranscription factor

Identifiers

PMID39354767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.