SynthesisBMC public health2024
Effect of non-pharmacological interventions in people with cognitive frailty: a systematic review and network meta-analysis.
Synthesis in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Aerobic exercise interventions for older adults with cognitive frailty: a systematic review.Frontiers in aging neuroscience · 2026Pooled it
- The effects of visual art therapy in older adults with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- The effects of virtual reality-based interventions on cognitive function, depressive symptoms, and daily functioning in older adults with mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2025Pooled it
- Trial
- Associations of malnutrition and hydration status with cognitive frailty in older adults.European geriatric medicine · 2026Article
- Influencing factors of cognitive frailty in older patients with esophageal cancer undergoing chemotherapy: a mixed-methods study.Frontiers in oncology · 2026Article
- Association Rule Analysis of Cognitive Frailty Subtypes in Community-Dwelling Older Adults.Clinical interventions in aging · 2026Article
- Prevalence and associated factors of cognitive frailty in older patients with lung cancer undergoing chemotherapy: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
absrtact
objectiveTo evaluate the effects of various non-pharmacological interventions on patients with cognitive impairment by systematic search and network meta-analysis, and to rank the effects of the included non-pharmacological interventions.
methodsThe databases of PubMed, Cochrane Library, EMbase, Web of Science, CNKI, VIP, WANFANG, and SinoMed were searched by computer. All randomized controlled trials (RCTs) of non-pharmacological interventions for people with cognitive frailty were collected. The search was conducted from 2000 to February 2024. Two reviewers independently screened the studies, extracted data, and assessed the risk of bias of the included studies, and then used Stata15 and R4.3.1 software to conduct network meta-analysis, with physical function and cognitive function as the main outcome indicators.
resultsA total of 19 randomized controlled trials involving 1738 patients were included. The results of network meta-analysis showed that among the non-pharmacological interventions, nutritional support had the best effect on improving frailty scores and cognitive function scores in patients with cognitive frailty. Aerobic training combined with resistance training is best for improving grip strength. For improving the patient's motor status, cognitive training had the best effect on improving TUG test scores. High-speed resistance training is best for improving walking speed.
conclusionThis review analyses the current study of non-pharmacological interventions to improve physical performance in patients with cognitive frailty. Current evidence suggests that nutritional support is most effective at improving physical frailty and cognitive decline in patients with cognitive frailty, and that exercise and cognitive training interventions significantly improve grip strength and motor ability.
trial registrationThis meta-analysis was prospectively registered with PROSPERO (registration number: CRD42023486881).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.