Evidence map›Paper›PMID 39354381›Full record

ArticleBMC pediatrics2024

Role of endothelial dysfunction in sleep-disordered breathing in egyptian children with sickle cell disease.

Ilham Youssry, Abla S Mostafa, Dina H Hamed, Yasmin F Abdel Hafez, Irene E Bishai, Yasmeen M M Selim

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In one paragraph

Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ilham YoussryDepartment of Pediatric Hematology, Faculty ofMedicine, Cairo University, Giza, Egypt.
Abla S MostafaDepartment of Pediatric Pulmonology, Faculty of Medicine, Cairo University, Giza, Egypt.
Dina H HamedDepartment of Pediatric Pulmonology, Faculty of Medicine, Cairo University, Giza, Egypt.
Yasmin F Abdel HafezDepartment of Pediatrics, Faculty of Medicine, Cairo University, Giza, Egypt.
Irene E BishaiDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Giza, Egypt.
Yasmeen M M SelimDepartment of Pediatric Hematology, Faculty ofMedicine, Cairo University, Giza, Egypt. yasmeenselim87@gmail.com.ORCID http://orcid.org/0000-0002-6423-7782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndothelial dysfunction is an integral pathophysiologic mechanism in sickle cell disease (SCD), and can lead to many complications. Sleep-disordered breathing (SDB) is a SCD complication with diverse incidence and pathophysiology. This study aimed to determine the prevalence of SDB in children with SCD and to assess its relation to endothelial dysfunction.

methodsSixty children with SCD and 60 healthy controls were enrolled. The levels of TNF-α, IL-6, and IL-17A were evaluated in the entire cohort using enzyme-linked immunosorbent assay (ELISA) kits. Polysomnography (PSG) was performed for all SCD patients after completion of the Pediatric Sleep Questionnaire (PSQ).

resultsTNF-α, IL-6, and IL-17A levels were significantly greater in children with SCD than in controls (p-values < 0.001, < 0.001, and 0.006, respectively). The PSQ revealed symptoms suggestive of SDB in 50 children with SCD (83.3%), and PSG revealed obstructive sleep apnea (OSA) in 44 children with SCD (73.3%); 22 patients had mild OSA, and 22 had moderate-to-severe OSA according to the apnea-hypopnea index (AHI). TNF-α was significantly greater in SCD children who reported heavy or loud breathing, trouble breathing or struggle to breathe, and difficulty waking up in the morning (p-values = 0.002, 0.002, and 0.031, respectively). The IL-6 levels were significantly greater in SCD children who stopped growing normally (p-value = 0.002). The levels of IL-6 and IL-17A were significantly greater in SCD children with morning headaches (p-values = 0.007 and 0.004, respectively).

conclusionChildren with SCD showed a high prevalence of SDB with significantly elevated levels of markers of endothelial function, highlighting the interplay of SDB and endothelial dysfunction in SCD.

Indexed as

Anemia, Sickle CellEndothelium, VascularInterleukin-6PolysomnographySleep Apnea SyndromesTumor Necrosis Factor-alphaAdolescentBiomarkersCase-Control StudiesChildCross-Sectional StudiesEgyptFemaleHumansInterleukin-17MaleBiomarkersIL17A protein, humanInterleukin-17Interleukin-6Tumor Necrosis Factor-alphaEndothelial dysfunctionSickle cell diseaseSleep disordered breathing

Identifiers

PMID39354381
PMCPMC11443814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.