Evidence map›Paper›PMID 39354379›Full record

ArticleBMC pediatrics2024

Maternal exposure to smoking and wheezing phenotypes in children: a cohort study of the Japan Environment and Children's Study.

Takuya Wada, Yuichi Adachi, Shokei Murakami, Yasunori Ito, Toshiko Itazawa, Akiko Tsuchida, Kenta Matsumura, Kei Hamazaki, Hidekuni Inadera, Japan Environment and Children’s Study Group

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Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Takuya WadaDepartment of Pediatrics, Faculty of Medicine, University of Toyama, Toyama, Japan.
Yuichi AdachiDepartment of Pediatrics, Faculty of Medicine, University of Toyama, Toyama, Japan. ydachi@icloud.com.
Shokei MurakamiDepartment of Pediatrics, Faculty of Medicine, University of Toyama, Toyama, Japan.
Yasunori ItoDepartment of Pediatrics, Faculty of Medicine, University of Toyama, Toyama, Japan.
Toshiko ItazawaDepartment of Pediatrics, Saitama Medical University, Saitama, Japan.
Akiko TsuchidaDepartment of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan.
Kenta MatsumuraDepartment of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan.
Kei HamazakiDepartment of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan.
Hidekuni InaderaDepartment of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan.
Japan Environment and Children’s Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have shown that prenatal maternal smoking and maternal secondhand smoke exposure during pregnancy were associated with an increased risk of wheezing and asthma development. However, few studies have examined the influence of different sources of tobacco exposure in different perinatal timeframes (preconception, prenatal, and postnatal) on wheezing phenotypes in children. Using national survey data from Japan, we investigated the effects of exposure to tobacco smoke during pregnancy on wheezing phenotypes in children before the age of 3 years.

methodsPregnant women who lived in the 15 regional centers in the Japan Environment and Children's Study were recruited. We obtained information on prenatal and postnatal exposure to active and secondhand smoke (SHS) and wheeze development up to 3 years of age. Multiple logistic regression analysis was performed to determine the association between tobacco smoke exposure and wheezing phenotypes in children.

resultsWe analyzed 73,057 singleton births and identified four longitudinal wheezing phenotypes: never wheezing; early transient wheezing (wheezing by age 1 year but not thereafter); late-onset wheezing (wheezing by age 2-3 years but not beforehand); and persistent wheezing. Maternal smoking during pregnancy was significantly associated with early transient and persistent wheezing in children compared with no maternal smoking [early transient wheezing: 1-10 cigarettes per day, adjusted odds ratio (aOR) 1.43, 95% confidence interval (CI) 1.23-1.66; ≥ 11 cigarettes per day, aOR 1.67, 95% CI 1.27-2.20; persistent wheezing: 1-10 cigarettes per day, aOR 1.64, 95% CI 1.37-1.97; ≥ 11 cigarettes per day, aOR 2.32, 95% CI 1.70-3.19]. Smoking cessation even before pregnancy was also significantly associated with increased risk of early transient wheezing, late-onset wheezing, and persistent wheezing in children. Moreover, maternal exposure to SHS during pregnancy was significantly associated with increased risk of early transient and persistent wheezing compared with no such exposure.

conclusionsMaternal smoking before and throughout pregnancy was associated with wheeze development in children up to 3 years of age. It appears that smoking is detrimental compared to never smoking, regardless of whether individuals quit smoking before or after becoming aware of the pregnancy.

Indexed as

Maternal ExposurePhenotypePrenatal Exposure Delayed EffectsRespiratory SoundsTobacco Smoke PollutionAdultChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornJapanMalePregnancyRisk FactorsTobacco Smoke PollutionAsthmaBirth cohortRespiratory soundsSecondhand smokeTobacco smokingWheeze trajectories

Identifiers

PMID39354379
PMCPMC11443675

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