Evidence map›Paper›PMID 39354314›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Rapid Analysis of Sterols in Blood-Derived Samples.

Ratna Budhi Pebriana, Selma Simsek, Marieke Heijink, Martin Giera

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ratna Budhi PebrianaLeiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, The Netherlands.
Selma SimsekLeiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, The Netherlands.
Marieke HeijinkLeiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, The Netherlands.
Martin GieraLeiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, The Netherlands. m.a.giera@lumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulations of cholesterol biosynthesis are known to be associated with several pathologies. Due to the rapid growth of clinical investigations in this research area, a specific, fast, and valid method for analyzing cholesterol, its precursors, and metabolites is required. Here, we describe a rapid method for sample preparation, separation, and quantification of sterols in blood-derived samples using polymeric solid phase extraction followed by gas chromatography-mass spectrometry. The validated method demonstrates a reliable quantification of cholesterol, its precursors, and metabolites.

Indexed as

CholesterolGas Chromatography-Mass SpectrometrySolid Phase ExtractionSterolsHumansCholesterolSterolsCholesterolGas chromatography-mass spectrometryHydroxycholesterolTargeted metabolomics

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.