Evidence map›Paper›PMID 39354249›Full record

ArticleAAPS PharmSciTech2024

An Exploration of Dissolution Tests for Inhalation Aerosols.

Min Wang, Zhaoying Fang, Kunhao Yang, Xiaowei Guo, Shangyang Li, Ali Liu

Abstract read
PubMed Publisher
In one paragraph

Article in AAPS PharmSciTech, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min WangSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Shandong, China.
Zhaoying FangShandong Engineering Research Center for New Drug Pharmaceuticals R&D, Linyi, Shandong, China.
Kunhao YangShandong Engineering Research Center for New Drug Pharmaceuticals R&D, Linyi, Shandong, China.
Xiaowei GuoShandong Engineering Research Center for New Drug Pharmaceuticals R&D, Linyi, Shandong, China.
Shangyang LiShandong Engineering Research Center for New Drug Pharmaceuticals R&D, Linyi, Shandong, China.
Ali LiuSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Shandong, China. liuali0208@163.com.ORCID http://orcid.org/0009-0005-5861-6064

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to establish a feasible dissolution method for inhalation aerosols. A method of collecting fine particles was investigated to capture aerosol particles less than 4 μm in diameter for dissolution tests. This dose collection method enabled the aerosol particles to be uniformly distributed on the glass fiber filter, thus considerably reducing particle agglomeration. Budesonide was used as a model drug. The aerodynamic particle size distribution (APSD) of the meter-dose inhaler (MDI) was compared by replacing actuators with different orifice sizes. Dissolution tests were conducted on fine particle doses collected using various actuators, and the dissolution profiles were modeled. The fine particle dose decreased with an increasing orifice size of the actuator. Actuators with different orifice sizes would affect the dissolution behavior of inhaled drugs. This finding was supported by similarity factor f

Indexed as

AerosolsBudesonideParticle SizeSolubilityAdministration, InhalationChemistry, PharmaceuticalMetered Dose InhalersAerosolsBudesonideaerosolbudesonidecascade impactordissolution test

Identifiers

PMID39354249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.