ArticleNature immunology2024
MrgprA3 neurons drive cutaneous immunity against helminths through selective control of myeloid-derived IL-33.
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Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
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Who cites it
17 citing papers in PubMed.
- T cell responses in repeated controlled human schistosome infection compared to natural exposure.Nature communications · 2025Trial
- IL-33 as a boundary-tissue state-transfer signal: a Reader-Alarmin-Effector architecture linking CNS and skin.Brain, behavior, & immunity - health · 2026Review
- Interleukin-33 and its receptor: multifaceted roles and emerging therapeutic potential.Nature reviews. Immunology · 2026Review
- Rewiring Atopic Dermatitis: Alarmin Cytokines at the Core of Barrier-Immune-Neuro-Microbiome Networks.Clinical reviews in allergy & immunology · 2026Review
- Sensory neurons shape γδ T cell effector programs to control Psoriasiform Inflammation.bioRxiv : the preprint server for biology · 2026Article
- Platelet-macrophage cooperation drives IL-33-dependent type 2 lung immunopathology in a sex-biased manner.The Journal of allergy and clinical immunology · 2026Article
- Review
- Mas-Related G-Protein-Coupled Receptors: Emerging Roles in Neuropathic Pain.Biomolecules · 2026Review
- Restoring balance in atopic disorders: insights into type 2 immunity and chronic inflammation.Frontiers in immunology · 2026Review
- Emerging zoonotic risk: molecular detection ofScience in One Health · 2026Article
- The avian schistosomeFood and waterborne parasitology · 2025Article
- TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Cercarial Dermatitis in Norway - An Emerging Zoonotic Disease.Acta parasitologica · 2025Article
- Sensory neurons on guard: roles in pathogen defense and host immunity.Current opinion in immunology · 2025Review
- From cercariae to chronic inflammation: understanding schistosome infection and host immune responses.Frontiers in immunology · 2025Review
- NaResearch (Washington, D.C.) · 2025Article
- Helminth-induced immune modulation in colorectal cancer: exploring therapeutic applications.Frontiers in immunology · 2025Review
Corrections and comments
- Update of
Authors and funding
19 authors.
Juan M Inclan-RicoDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1134-9139
Camila M NapuriDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Cailu LinMonell Chemical Senses Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8909-7758
Li-Yin HungDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Annabel A FergusonDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Xiaohong LiuDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Qinxue WuDepartment of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Christopher F PastoreDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1002-6138
Adriana StephensonDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ulrich M FemoeDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8715-152X
Fungai MusaigwaDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-0216-0385
Heather L RossiDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Bruce D FreedmanDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Danielle R ReedMonell Chemical Senses Center, Philadelphia, PA, USA.
Tomáš MacháčekDepartment of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-6310-4099
Petr HorákDepartment of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.ORCID http://orcid.org/0000-0001-9820-5044
Ishmail Abdus-SaboorDepartment of Biological Sciences, Zuckerman Mind, Brain, Behavior Institute, Columbia University, New York, NY, USA.
Wenqin LuoDepartment of Neuroscience, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
De'Broski R HerbertDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA. debroski@vet.upenn.edu.ORCID http://orcid.org/0000-0002-2449-5365
Funding
University of Pennsylvania Postdoctoral Opportunities in Research and TeachingK12GM081259 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Janis K. Burkhardt · 2007 to 2026
$20.1MPARASITOLOGY: MODERN APPROACHEST32AI007532 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 1998 to 2022
$5.0MUsing Mouse Pain Scales to Discover Unusual Pain Sensitivity and New Pain TargetsDP2NS130454 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ABDUS-SABOOR, ISHMAIL JOHN · 2022 to 2023
$2.5MPerforin 2 controls unconventional cytokine release from mucosal APCU01AI163062 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2021 to 2025
$2.4MNeuro-Immune mechanisms against skin-penetrating helminthsR01AI185041 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI De'Broski R Herbert · 2024 to 2026
$2.1MPhysiological roles of schistosome TRP ion channels with atypical pharmacologyR01AI123173 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2017 to 2021
$2.0MMyeloid derived IL-33 controls Treg responses during parasite infectionR01AI164715 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2021 to 2024
$1.6MCentral role for skin sensory neurons in anti-helminth immunityR21AI171740 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R, ROSSI, HEATHER L · 2023 to 2024
$447kNeuronal regulation of sinonasal Type 2 inflammationR21AI173476 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R, ROSSI, HEATHER L · 2023 to 2024
$447kNIAID NIH HHS R01 AI123173NIAID NIH HHS R01 AI164715NIAID NIH HHS R01 AI185041NIAID NIH HHS R21 AI171740NIAID NIH HHS R21 AI173476NIAID NIH HHS T32 AI007532NIAID NIH HHS U01 AI163062NIGMS NIH HHS K12 GM081259NINDS NIH HHS DP2 NS130454U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01 AI123173-05U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01 AI164715-01U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32 AI007532-24U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U01 AI163062-01
Abstract
Skin uses interdependent cellular networks for barrier integrity and host immunity, but most underlying mechanisms remain obscure. Herein, we demonstrate that the human parasitic helminth Schistosoma mansoni inhibited pruritus evoked by itch-sensing afferents bearing the Mas-related G-protein-coupled receptor A3 (MrgprA3) in mice. MrgprA3 neurons controlled interleukin (IL)-17
Indexed as
Interleukin-33Receptors, G-Protein-CoupledSchistosoma mansoniSchistosomiasis mansoniAnimalsDendritic CellsHumansMacrophagesMiceMice, Inbred C57BLMice, KnockoutMyeloid CellsNeuronsPruritusSkinIl33 protein, mouseInterleukin-33Receptors, G-Protein-Coupled
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.