Evidence map›Paper›PMID 39354094›Full record

ArticleScientific reports2024

Phenotypic evidence of deltamethrin resistance and identification of selective sweeps in Anopheles mosquitoes on the Bijagós Archipelago, Guinea-Bissau.

Sophie Moss, Robert T Jones, Elizabeth Pretorius, Eunice Teixeira da Silva, Matthew Higgins, Mojca Kristan, Holly Acford-Palmer, Emma L Collins, Amabelia Rodrigues, Sanjeev Krishna and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sophie MossFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. sophie.moss@lshtm.ac.uk.
Robert T JonesFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Elizabeth PretoriusFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Eunice Teixeira da SilvaProjecto de Saúde Bandim, Bissau, Guinea-Bissau.
Matthew HigginsFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Mojca KristanFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Holly Acford-PalmerFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Emma L CollinsFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Amabelia RodriguesProjecto de Saúde Bandim, Bissau, Guinea-Bissau.
Sanjeev KrishnaClinical Academic Group, Institute for Infection and Immunity, and St, George's University Hospitals NHS Foundation Trust, St. George's University of London, London, UK.
Taane G ClarkFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Anna LastFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Susana CampinoFaculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.

Funding

Joint Global Health Trials Scheme MRC, Wellcome Trust, UKRI, NIHR, Grant no. MR/S005013/1Medical Research Council MR/N013638/1UK Research and Innovation BBSRC BB/X018156/1; MRC IAA2129, MR/R026297/1, and MR/X005895/1; EPSRC EP/Y018842/1Wellcome Trust
6 · The paper itself

Abstract

Vector control in the Bijagós Archipelago of Guinea-Bissau currently relies on pyrethroid insecticide-treated nets. However, data on insecticide resistance in Guinea-Bissau is limited. This study identified deltamethrin resistance in the Anopheles gambiae sensu lato complex on Bubaque island using WHO tube tests in November 2022. Whole genome sequencing of An. gambiae sensu stricto mosquitoes identified six single nucleotide polymorphisms (SNPs) previously associated with, or putatively associated with, insecticide resistance: T791M, L995F, N1570Y, A1746S and P1874L in the vgsc gene, and L119V in the gste2 gene. Twenty additional non-synonymous SNPs were identified in insecticide-resistance associated genes. Four of these SNPs were present at frequencies over 5% in the population: T154S, I126F and G26S in the vgsc gene and A65S in ace1. Genome wide selection scans using Garud's H

Indexed as

AnophelesInsecticide ResistanceInsecticidesNitrilesPolymorphism, Single NucleotidePyrethrinsAnimalsGuinea-BissauInsect ProteinsMosquito VectorsPhenotypeSelection, GeneticdecamethrinInsecticidesInsect ProteinsNitrilesPyrethrins

Identifiers

PMID39354094
PMCPMC11445403

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.