Evidence map›Paper›PMID 39354067›Full record

ArticleJournal of human hypertension2024

The association of leptin and incident hypertension in the reasons for geographic and racial differences in stroke (REGARDS) cohort.

S E Sherman, E Stoutenburg, D L Long, S P Juraschek, M Cushman, V J Howard, R P Tracy, S E Judd, D Kamin Mukaz, N A Zakai and 1 more

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of human hypertension, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. American journal of preventive cardiology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

S E ShermanDepartment of Medicine, Tulane University School of Medicine, New Orleans, LA, USA. ssherman3@tulane.edu.ORCID 0009-0006-5954-1305
E StoutenburgUniversity of Vermont Larner College of Medicine, Burlington, VT, USA.ORCID 0009-0001-2639-1260
D L LongDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-8614-7190
S P JuraschekDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0003-4168-2696
M CushmanDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA.ORCID 0000-0002-7871-6143
V J HowardDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
R P TracyDepartment of Biochemistry, University of Vermont Larner College of Medicine, Burlington, VT, USA.
S E JuddDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
D Kamin MukazDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA.
N A ZakaiDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA.
T B PlanteDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

Leptin is an adipokine associated with obesity and with hypertension in animal models. Whether leptin is associated with hypertension independent of obesity is unclear. Relative to White adults, Black adults have higher circulating leptin concentration. As such, leptin may mediate some of the excess burden of incident hypertension among Black adults. REGARDS enrolled 30,239 adults aged ≥45 years from 48 US states in 2003-07. Baseline leptin was measured in a sex- and race-stratified sample of 4400 participants. Modified Poisson regression estimated relative risk (RR) of incident hypertension (new ≥140/≥90 mmHg threshold or use of antihypertensives) per SD of log-transformed leptin, stratified by obesity (BMI of 30 kg/m

Indexed as

Black or African AmericanHypertensionLeptinObesityAgedBiomarkersBlood PressureBody Mass IndexFemaleHumansIncidenceMaleMiddle AgedRisk AssessmentRisk FactorsStrokeBiomarkersLEP protein, humanLeptin

Identifiers

PMID39354067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.