ArticleNPJ systems biology and applications2024
Systems biology approach for enhancing limonene yield by re-engineering Escherichia coli.
Article in NPJ systems biology and applications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Elucidating the biochemical properties of limonene synthase from Agastache rugosa.BMC plant biology · 2026Article
- Solid-state platform (SSP) to produce terpenes from enzymatically treated textile waste withRSC advances · 2026Article
- Kinetic modeling of terpenoid production in E. coli: insights into subpopulation emergence and process optimization.Microbial cell factories · 2025Article
- Advances in the sustainable biosynthesis of valuable terpenoid flavor compounds and precursors in micro-organisms.Biotechnology for biofuels and bioproducts · 2025Review
- Enhancing limonene production by probing the metabolic network through time-series metabolomics data.Metabolomics : Official journal of the Metabolomic Society · 2025Article
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Authors and funding
5 authors.
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Abstract
Engineered microorganisms have emerged as viable alternatives for limonene production. However, issues such as low enzyme abundance or activities, and regulatory feedback/forward inhibition may reduce yields. To understand the underlying metabolism, we adopted a systems biology approach for an engineered limonene-producing Escherichia coli strain K-12 MG1655. Firstly, we generated time-series metabolomics data and, secondly, developed a dynamic model based on enzyme dynamics to track the native metabolic networks and the engineered mevalonate pathway. After several iterations of model fitting with experimental profiles, which also included
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