Evidence map›Paper›PMID 39353950›Full record

ArticleNature communications2024

A sexually transmitted sugar orchestrates reproductive responses to nutritional stress.

Seong-Jin Kim, Kang-Min Lee, Si Hyung Park, Taekyun Yang, Ingyu Song, Fumika Rai, Ryo Hoshino, Minsik Yun, Chen Zhang, Jae-Il Kim and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Venerose: a nuptial gift with implications.Journal of neurogenetics · 2025
    Article
  5. Synaptic connectome of a neurosecretory network in thebioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Seong-Jin Kim *School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.ORCID 0000-0003-1673-8328
Kang-Min Lee *School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.ORCID 0000-0002-0546-8273
Si Hyung ParkSchool of Horticulture and Forestry, College of Bio and Medical Sciences, Mokpo National University, Muan, 58554, Republic of Korea.
Taekyun YangSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Ingyu SongSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Fumika RaiGraduate School of Science and Technology, University of Tsukuba, Tsukuba, Ibaraki, 305-8572, Japan.
Ryo HoshinoGraduate School of Science and Technology, University of Tsukuba, Tsukuba, Ibaraki, 305-8572, Japan.
Minsik YunSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.ORCID 0000-0002-0011-0942
Chen ZhangSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.ORCID 0000-0001-9494-1378
Jae-Il KimSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Sunjae LeeSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.
Greg S B SuhDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.ORCID 0000-0003-4381-658X
Ryusuke NiwaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki, 305-8577, Japan.ORCID 0000-0002-1716-455X
Zee-Yong ParkSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.ORCID 0000-0002-8184-5982
Young-Joon KimSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea. kimyj@gist.ac.kr.ORCID 0000-0002-7990-754X

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 22H00414National Research Foundation of Korea (NRF) 2018R1A2A1A05079359National Research Foundation of Korea (NRF) 2019R1A4A1029724National Research Foundation of Korea (NRF) 2022M3E5E8081194National Research Foundation of Korea (NRF) 2022M3H9A1085169National Research Foundation of Korea (NRF) 2022R1A2C3008091
6 · The paper itself

Abstract

Seminal fluid is rich in sugars, but their role beyond supporting sperm motility is unknown. In this study, we found Drosophila melanogaster males transfer a substantial amount of a phospho-galactoside to females during mating, but only half as much when undernourished. This seminal substance, which we named venerose, induces an increase in germline stem cells (GSCs) and promotes sperm storage in females, especially undernourished ones. Venerose enters the hemolymph and directly activates nutrient-sensing Dh44

Indexed as

Drosophila melanogasterReproductionSexual Behavior, AnimalAnimalsBrainDrosophila ProteinsFemaleHemolymphMaleNeuronsNeuropeptidesSemenSpermatozoaSperm MotilityStress, PhysiologicalSugarsDrosophila ProteinsNeuropeptidesSugars

Identifiers

PMID39353950
PMCPMC11445483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.