ArticleTranslational psychiatry2024
Contribution of resting-state functional connectivity of the subgenual anterior cingulate to prediction of antidepressant efficacy in patients with major depressive disorder.
Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predicting the treatment outcomes of major depressive disorder interventions with baseline resting-state functional connectivity: a meta-analysis.BMC psychiatry · 2025Pooled it
- Accelerated TMS is associated with changes of subgenual cingulate-default mode network coupling in depression: an observational 7 Tesla fMRI study.European archives of psychiatry and clinical neuroscience · 2026Article
- Resting-state fMRI-based machine learning for predicting SSRI treatment response in major depressive disorder.BMC psychiatry · 2026Article
- Artificial Intelligence in Drug Discovery and Development: Raising Quality per Decision.Pharmacopsychiatry · 2026Review
- Functional inputs to the subgenual cingulate cortex differentiate levels of depressive symptom severity in neurotypical young adults: granger causality and clustering analyses.The international journal of neuropsychopharmacology · 2026Article
- Altered subgenual anterior cingulate cortex connectivity in psoriasis patients with depression: a resting-state fMRI case-control study.Annals of general psychiatry · 2026Article
- Frontocingulate-parietal-limbic circuits associated with both ruminative brooding and self-regulatory processes.Frontiers in human neuroscience · 2026Article
- Power Spectral Slope as a Novel Brain Functional Marker for Major Depressive Disorder.Biological psychiatry global open science · 2026Article
- Abnormal Resting-State Functional Connectivity Between the Dorsal Anterior Cingulate Cortex and the Limbic System Contributes to Pain and Emotion Regulation Impairment in Fibromyalgia Patients.International journal of rheumatic diseases · 2026Article
- Intranasal (R)-ketamine modulates depression symptom and neurotransmitters-associated human brain connectivity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- A Study on dynamic functional connectivity and efficacy prediction of SAINT for rapid antidepressant effects and relief of suicidal ideation.Translational psychiatry · 2025Article
- Differential brain regional activity and connectivity of anterior cingulate cortex between major depressive disorder with and without suicidal ideation under resting state.Psychological medicine · 2025Article
- Systematical Comparison Reveals Distinct Brain Transcriptomic Characteristics in Depression Models Induced by Gut Microbiota Dysbiosis and Chronic Stress.Molecular neurobiology · 2025Article
- Resting-state fMRI graph theory analysis for predicting selective serotonin reuptake inhibitors treatment response in adolescent major depressive disorder.Frontiers in psychiatry · 2025Article
- Towards closed-loop precision psychiatry: Integrating MRI biomarkers for individualized care of major depressive disorder.Psychoradiology · 2025Review
- Examining anterior prefrontal cortex resting-state functional connectivity patterns associated with depressive symptoms in chronic moderate-to-severe traumatic brain injury.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated how resting-state functional connectivity (rsFC) of the subgenual anterior cingulate cortex (sgACC) predicts antidepressant response in patients with major depressive disorder (MDD). Eighty-seven medication-free MDD patients underwent baseline resting-state functional MRI scans. After 12 weeks of escitalopram treatment, patients were classified into remission depression (RD, n = 42) and nonremission depression (NRD, n = 45) groups. We conducted two analyses: a voxel-wise rsFC analysis using sgACC as a seed to identify group differences, and a prediction model based on the sgACC rsFC map to predict treatment efficacy. Haufe transformation was used to interpret the predictive rsFC features. The RD group showed significantly higher rsFC between the sgACC and regions in the fronto-parietal network (FPN), including the bilateral dorsolateral prefrontal cortex (DLPFC) and bilateral inferior parietal lobule (IPL), compared to the NRD group. These sgACC rsFC measures correlated positively with symptom improvement. Baseline sgACC rsFC also significantly predicted treatment response after 12 weeks, with a mean accuracy of 72.64% (p < 0.001), mean area under the curve of 0.74 (p < 0.001), mean specificity of 0.82, and mean sensitivity of 0.70 in 10-fold cross-validation. The predictive voxels were mainly within the FPN. The rsFC between the sgACC and FPN is a valuable predictor of antidepressant response in MDD patients. These findings enhance our understanding of the neurobiological mechanisms underlying treatment response and could help inform personalized treatment strategies for MDD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.