ArticleNature communications2024
Potentiation of cortico-spinal output via targeted electrical stimulation of the motor thalamus.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07056348 (Chronic Stimulation of the Motor Ventral Thalamus), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Stimulation of the Motor Ventral Thalamus (VOP/VIM) for Motor Control in Humans
Who cites it
9 citing papers in PubMed.
- Unveiling Functional Architecture of Human Thalamus: AStereoelectroencephalography Study.MedComm · 2026Article
- Frequency-dependent effects of motor thalamus deep brain stimulation on speech and swallowing.Nature communications · 2026Article
- Motor Recovery After a Hemispherectomy: Review of Mechanisms and the Potential of Neuromodulation to Enhance Motor Outcomes.Journal of child neurology · 2026Review
- Review
- Shared somatosensory-motor neural population dynamics track motor recovery after stroke.bioRxiv : the preprint server for biology · 2026Article
- Article
- An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys.Journal of neuroscience methods · 2024Article
- The evolution of neuromodulation for chronic stroke: From neuroplasticity mechanisms to brain-computer interfaces.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Effects of low-frequency burst stimulation of the motor thalamus on cortical neural co-firing.Brain stimulationArticle
Corrections and comments
- Update of
Authors and funding
18 authors.
Funding
Abstract
Cerebral white matter lesions prevent cortico-spinal descending inputs from effectively activating spinal motoneurons, leading to loss of motor control. However, in most cases, the damage to cortico-spinal axons is incomplete offering a potential target for therapies aimed at improving volitional muscle activation. Here we hypothesize that, by engaging direct excitatory connections to cortico-spinal motoneurons, stimulation of the motor thalamus could facilitate activation of surviving cortico-spinal fibers thereby immediately potentiating motor output. To test this hypothesis, we identify optimal thalamic targets and stimulation parameters that enhance upper-limb motor-evoked potentials and grip forces in anesthetized monkeys. This potentiation persists after white matter lesions. We replicate these results in humans during intra-operative testing. We then design a stimulation protocol that immediately improves strength and force control in a patient with a chronic white matter lesion. Our results show that electrical stimulation targeting surviving neural pathways can improve motor control after white matter lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.