Evidence map›Paper›PMID 39353897›Full record

ArticleCell death & disease2024

Deciphering the impact of PROM1 alternative splicing on human photoreceptor development and maturation.

Marina Moya-Molina, Birthe Dorgau, Emily Flood, Stef J F Letteboer, Esben Lorentzen, Jonathan Coxhead, Graham Smith, Ronald Roepman, Sushma Nagaraja Grellscheid, Lyle Armstrong and 1 more

Abstract read
In one paragraph

Article in Cell death & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marina Moya-MolinaBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-4787-3015
Birthe DorgauBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0003-4031-4402
Emily FloodBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Stef J F LetteboerDepartment of Human Genetics, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.
Esben LorentzenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.
Jonathan CoxheadBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Graham SmithBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Ronald RoepmanDepartment of Human Genetics, Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-5178-8163
Sushma Nagaraja GrellscheidDepartment of Biosciences, Durham University, Durham, UK.
Lyle ArmstrongBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Majlinda LakoBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK. majlinda.lako@ncl.ac.uk.ORCID 0000-0003-1327-8573

Funding

Medical Research Council MR/T017503/1Medical Research Council MR/X001687/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C016106/1Wellcome Trust
6 · The paper itself

Abstract

Alternative splicing (AS) is a crucial mechanism contributing to proteomic diversity, which is highly regulated in tissue- and development-specific patterns. Retinal tissue exhibits one of the highest levels of AS. In particular, photoreceptors have a distinctive AS pattern involving the inclusion of microexons not found in other cell types. PROM1 whose encoded protein Prominin-1 is located in photoreceptor outer segments (OSs), undergoes exon 4 inclusion from the 12

Indexed as

AC133 AntigenAlternative SplicingExonsHumansOrganoidsPhotoreceptor Cells, VertebrateRetinaAC133 AntigenPROM1 protein, human

Identifiers

PMID39353897
PMCPMC11445533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.