Evidence map›Paper›PMID 39353892›Full record

ArticleCell death & disease2024

MAT2B regulates the protein level of MAT2A to preserve RNA N6-methyladenosine.

Xinyi Wan, Weiwu Zeng, Haonan Fan, Chenliang Wang, Shixun Han, Zhongxing Sun, Mei Tang, Juejia Shao, Yu Liu, Yuan Fang and 5 more

Abstract read
In one paragraph

Article in Cell death & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Posttranslational Regulation of Mammalian Sulfur Amino Acid Metabolism.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xinyi Wan *The Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Weiwu Zeng *The Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Haonan Fan *The Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Chenliang WangLife Sciences Institute, Zhejiang University, Hangzhou, China.
Shixun HanLife Sciences Institute, Zhejiang University, Hangzhou, China.
Zhongxing SunThe Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Mei TangLife Sciences Institute, Zhejiang University, Hangzhou, China.
Juejia ShaoThe Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Yu LiuThe Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Yuan FangThe Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Junqi JiaThe Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Yin TangThe Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Yanjun ZhangThe Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Bin ZhaoLife Sciences Institute, Zhejiang University, Hangzhou, China.ORCID 0000-0002-1690-646X
Dong FangThe Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou, China. dfang@zju.edu.cn.ORCID 0000-0002-9807-5224

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MAT2B works together with MAT2A to synthesize S-Adenosyl methionine (SAM) as the primary methyl donor. MAT2B, despite lacking catalytic activity, exerts regulatory control over the enzymatic activity of MAT2A. In addition to the enzymatic activity regulation, we find that, in an NADP

Indexed as

AdenosineLiver NeoplasmsMethionine AdenosyltransferaseAnimalsCell Line, TumorHumansMiceNADPProtein BindingRNA, MessengerS-AdenosylmethionineAdenosineMAT2A protein, humanMAT2B protein, humanMethionine AdenosyltransferaseNADPN-methyladenosineRNA, MessengerS-Adenosylmethionine

Identifiers

PMID39353892
PMCPMC11445541

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.