Trial reportBMJ open2024
Genicular artery embolisation versus sham embolisation for symptomatic osteoarthritis of the knee: a randomised controlled trial.
Trial report in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Novel Transcatheter Arterial Embolization for Treatment of Knee Osteoarthritis: a Randomized Sham-controlled Clinical Trial
Percutaneous Transcatheter Genicular Embolization in Osteoarthritis
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Outcome and Safety of Genicular Artery Embolization for Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Cardiovascular and interventional radiology · 2026Pooled it
- Transarterial Embolization in Osteoarthritis of the Knee: Mechanism of Action and Current Results.Deutsches Arzteblatt international · 2026Pooled it
- Long-term outcomes of genicular artery embolization for knee osteoarthritis: 12-month efficacy and secondary outcomes from a randomized sham-controlled clinical trial.European radiology · 2026Trial
- Transarterial embolization in musculoskeletal care: an indication-stratified narrative review.CVIR endovascular · 2026Review
- Musculoskeletal Embolization: Are We Witnessing Evidence-Based Progress or Evidence-Limited Enthusiasm?Cardiovascular and interventional radiology · 2026Article
- Genicular Artery Embolization for Chronic Knee Pain: Expert Consensus Recommendations on Indications, Technique and Clinical Care Using a Delphi Process.Cardiovascular and interventional radiology · 2026Article
- Genicular artery embolization as a minimally invasive treatment for knee osteoarthritis: systematic review and meta-analysis.Skeletal radiology · 2026Article
- Genicular artery embolization for knee osteoarthritis: Is the emperor wearing no clothes?European radiology · 2026Article
- Percutaneous denervation for the treatment of knee pain.Skeletal radiology · 2026Review
- Periarticular Embolization as an Alternative Treatment for Surgery-Ineligible Patients with Hip Osteoarthritis: A Prospective Comparative Study.Journal of clinical medicine · 2026Article
- [Anatomy of the genicular arteries-What interventional radiologists should know].Radiologie (Heidelberg, Germany) · 2026Review
- [Transarterial periarticular embolization as a treatment option for chronic joint pain].Radiologie (Heidelberg, Germany) · 2026Review
- Genicular artery embolization for treating knee osteoarthritis - an overview of the evidence.Pain management · 2026Review
- Editorial: Special issue imaging and pain.Osteoarthritis imaging · 2026Article
- Potential Predictors of Pain and Stiffness Response Following Genicular Artery Embolization for Knee Osteoarthritis.Journal of clinical medicine · 2026Article
- Dynamic contrast-enhanced magnetic resonance imaging of the synovium and synovial subregions in knee osteoarthritis: test-retest repeatability.Quantitative imaging in medicine and surgery · 2026Article
- Perspective: Genicular artery embolization for knee osteoarthritis - When the hype doesn't match the evidence.Osteoarthritis imaging · 2025Article
- Genicular Artery Embolization using an Ethiodized Oil-based Emulsion in Fifty Knees: 12-Month Results.Cardiovascular and interventional radiology · 2025Article
- Genicular Artery Embolization in Knee Osteoarthritis: Bringing Imaging and Machine Learning Into the 21st Century.Cardiovascular and interventional radiology · 2025Article
- Genicular Artery Embolization for Symptomatic Knee Osteoarthritis: A Comprehensive Review of Techniques and Clinical Outcomes.Cardiovascular and interventional radiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the efficacy of genicular artery embolisation (GAE) compared with sham GAE for pain reduction in patients with symptomatic mild-to-moderate knee osteoarthritis (KOA).
designDouble-blind randomised sham-controlled clinical trial conducted from June 2019 to December 2021. The follow-up period was 4 months.
settingSingle-centre study conducted at a university medical centre in Rotterdam, Netherlands.
participants58 adults with symptomatic mild-to-moderate KOA not improving with conservative treatment.
interventionsParticipants were randomised to receive either GAE treatment or a sham GAE treatment.
main outcome measuresThe primary outcome was reduction of pain measured with the Knee Injury and Osteoarthritis Outcome Score pain subscale (0-100, with 0 representing the worst pain outcome and 100 the best) after 4 months. Outcomes were assessed at baseline and 1 and 4 months.
resultsFrom June 2019 to December 2021, 58 patients were included. 29 patients were randomised to the GAE group and 29 to the sham group. All participants completed the study. The mean pain reduction after 4 months was 21.4 (95% CI 13.9 to 28.8) for the GAE group and 18.4 points (95% CI 11.6 to 25.1) for the sham group. The between-group difference for the mean pain reduction was 3.0 (95% CI -7.1 to 13.0) with an estimated Cohen's d effect size of d = 0.15 (95% CI -0.37 to 0.66). Group allocation was not a significant contributor to pain reduction (p = 0.31). No serious adverse events (AEs) occurred. 23 mild AEs occurred in the GAE group and 5 in the sham group.
conclusionWe did not establish a clinical effect of GAE in patients with mild-to-moderate KOA as GAE produced a similar effect on pain reduction as a sham GAE procedure. TRIAL REGISTRATION NUMBER: NCT03884049.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.