Evidence map›Paper›PMID 39353631›Full record

ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2024

SARS-CoV-2, Tdap, and influenza vaccination during pregnancy from 2019 to 2022 in Ontario, Canada: a population-based retrospective cohort study.

Devon Greyson, Rebecca Correia, Michelle Howard, Elizabeth K Darling, David Kirkwood, Amie Davis, Caroline Mniszak, Aaron Jones, Monica Molinaro, Meredith Vanstone

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05663762 (How do Perceptions of Coronavirus Disease), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05663762 completednot on this map

How do Perceptions of Coronavirus Disease (COVID-19) Risk Influence Health Decisions in Pregnancy?

TypeobservationalSponsorMcMaster UniversityRan2022 to 2024Enrolled136,500ConditionsPregnancy Related
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Devon GreysonSchool of Population and Public Health (Greyson, Mniszak), University of British Columbia; Vaccine Evaluation Center (Greyson), British Columbia Children's Hospital Research Institute, Vancouver, BC; Department of Family Medicine (Correia, Howard, Davis, Molinaro, Vanstone), and Department of Obstetrics and Gynecology (Darling), and ICES McMaster (Darling, Jones), and Department of Health Research Methods, Evidence and Impact (Darling, Jones), McMaster University, Hamilton, Ont.; Institute for Health Sciences Education (Kirkwood, Molinaro), McGill University, Montréal, Que.; Centre for Health Economics and Policy Analysis (Vanstone), McMaster University, Hamilton, Ont. devon.greyson@ubc.ca.
Rebecca CorreiaSchool of Population and Public Health (Greyson, Mniszak), University of British Columbia; Vaccine Evaluation Center (Greyson), British Columbia Children's Hospital Research Institute, Vancouver, BC; Department of Family Medicine (Correia, Howard, Davis, Molinaro, Vanstone), and Department of Obstetrics and Gynecology (Darling), and ICES McMaster (Darling, Jones), and Department of Health Research Methods, Evidence and Impact (Darling, Jones), McMaster University, Hamilton, Ont.; Institute for Health Sciences Education (Kirkwood, Molinaro), McGill University, Montréal, Que.; Centre for Health Economics and Policy Analysis (Vanstone), McMaster University, Hamilton, Ont.
Michelle HowardSchool of Population and Public Health (Greyson, Mniszak), University of British Columbia; Vaccine Evaluation Center (Greyson), British Columbia Children's Hospital Research Institute, Vancouver, BC; Department of Family Medicine (Correia, Howard, Davis, Molinaro, Vanstone), and Department of Obstetrics and Gynecology (Darling), and ICES McMaster (Darling, Jones), and Department of Health Research Methods, Evidence and Impact (Darling, Jones), McMaster University, Hamilton, Ont.; Institute for Health Sciences Education (Kirkwood, Molinaro), McGill University, Montréal, Que.; Centre for Health Economics and Policy Analysis (Vanstone), McMaster University, Hamilton, Ont.
Elizabeth K DarlingSchool of Population and Public Health (Greyson, Mniszak), University of British Columbia; Vaccine Evaluation Center (Greyson), British Columbia Children's Hospital Research Institute, Vancouver, BC; Department of Family Medicine (Correia, Howard, Davis, Molinaro, Vanstone), and Department of Obstetrics and Gynecology (Darling), and ICES McMaster (Darling, Jones), and Department of Health Research Methods, Evidence and Impact (Darling, Jones), McMaster University, Hamilton, Ont.; Institute for Health Sciences Education (Kirkwood, Molinaro), McGill University, Montréal, Que.; Centre for Health Economics and Policy Analysis (Vanstone), McMaster University, Hamilton, Ont.
David KirkwoodSchool of Population and Public Health (Greyson, Mniszak), University of British Columbia; Vaccine Evaluation Center (Greyson), British Columbia Children's Hospital Research Institute, Vancouver, BC; Department of Family Medicine (Correia, Howard, Davis, Molinaro, Vanstone), and Department of Obstetrics and Gynecology (Darling), and ICES McMaster (Darling, Jones), and Department of Health Research Methods, Evidence and Impact (Darling, Jones), McMaster University, Hamilton, Ont.; Institute for Health Sciences Education (Kirkwood, Molinaro), McGill University, Montréal, Que.; Centre for Health Economics and Policy Analysis (Vanstone), McMaster University, Hamilton, Ont.
Amie DavisSchool of Population and Public Health (Greyson, Mniszak), University of British Columbia; Vaccine Evaluation Center (Greyson), British Columbia Children's Hospital Research Institute, Vancouver, BC; Department of Family Medicine (Correia, Howard, Davis, Molinaro, Vanstone), and Department of Obstetrics and Gynecology (Darling), and ICES McMaster (Darling, Jones), and Department of Health Research Methods, Evidence and Impact (Darling, Jones), McMaster University, Hamilton, Ont.; Institute for Health Sciences Education (Kirkwood, Molinaro), McGill University, Montréal, Que.; Centre for Health Economics and Policy Analysis (Vanstone), McMaster University, Hamilton, Ont.
Caroline MniszakSchool of Population and Public Health (Greyson, Mniszak), University of British Columbia; Vaccine Evaluation Center (Greyson), British Columbia Children's Hospital Research Institute, Vancouver, BC; Department of Family Medicine (Correia, Howard, Davis, Molinaro, Vanstone), and Department of Obstetrics and Gynecology (Darling), and ICES McMaster (Darling, Jones), and Department of Health Research Methods, Evidence and Impact (Darling, Jones), McMaster University, Hamilton, Ont.; Institute for Health Sciences Education (Kirkwood, Molinaro), McGill University, Montréal, Que.; Centre for Health Economics and Policy Analysis (Vanstone), McMaster University, Hamilton, Ont.
Aaron JonesSchool of Population and Public Health (Greyson, Mniszak), University of British Columbia; Vaccine Evaluation Center (Greyson), British Columbia Children's Hospital Research Institute, Vancouver, BC; Department of Family Medicine (Correia, Howard, Davis, Molinaro, Vanstone), and Department of Obstetrics and Gynecology (Darling), and ICES McMaster (Darling, Jones), and Department of Health Research Methods, Evidence and Impact (Darling, Jones), McMaster University, Hamilton, Ont.; Institute for Health Sciences Education (Kirkwood, Molinaro), McGill University, Montréal, Que.; Centre for Health Economics and Policy Analysis (Vanstone), McMaster University, Hamilton, Ont.
Monica MolinaroSchool of Population and Public Health (Greyson, Mniszak), University of British Columbia; Vaccine Evaluation Center (Greyson), British Columbia Children's Hospital Research Institute, Vancouver, BC; Department of Family Medicine (Correia, Howard, Davis, Molinaro, Vanstone), and Department of Obstetrics and Gynecology (Darling), and ICES McMaster (Darling, Jones), and Department of Health Research Methods, Evidence and Impact (Darling, Jones), McMaster University, Hamilton, Ont.; Institute for Health Sciences Education (Kirkwood, Molinaro), McGill University, Montréal, Que.; Centre for Health Economics and Policy Analysis (Vanstone), McMaster University, Hamilton, Ont.
Meredith VanstoneSchool of Population and Public Health (Greyson, Mniszak), University of British Columbia; Vaccine Evaluation Center (Greyson), British Columbia Children's Hospital Research Institute, Vancouver, BC; Department of Family Medicine (Correia, Howard, Davis, Molinaro, Vanstone), and Department of Obstetrics and Gynecology (Darling), and ICES McMaster (Darling, Jones), and Department of Health Research Methods, Evidence and Impact (Darling, Jones), McMaster University, Hamilton, Ont.; Institute for Health Sciences Education (Kirkwood, Molinaro), McGill University, Montréal, Que.; Centre for Health Economics and Policy Analysis (Vanstone), McMaster University, Hamilton, Ont.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHesitancy about vaccination during pregnancy posed challenges to SARS-CoV-2 vaccination efforts. We aimed to examine rates of SARS-CoV-2 vaccination among Ontario residents who gave birth in early 2022, and to compare rates of SARS-CoV-2 vaccine uptake with rates of tetanus, diphtheria, and pertussis (Tdap) and influenza vaccination during pregnancy in 2019, 2021, and 2022.

methodsWe conducted a population-based retrospective cohort study to describe vaccination rates among pregnant and comparable nonpregnant populations in Ontario using linked administrative data. Provincially insured females who had a live, in-hospital birth from Jan. 1 to Mar. 31 in 2019, 2021, or 2022 were our primary cohort. Using log-binomial regression, we tested associations between SARS-CoV-2 (2022) and Tdap and influenza (2019, 2021, 2022) vaccination status, with birth group and covariates. We compared SARS-CoV-2 vaccination status with the status of a matched cohort of nonpregnant females and conducted subgroup analyses by age and prenatal clinician type.

resultsAmong birthing people, 78.7% received their first SARS-CoV-2 vaccine dose and 74.2% received a second dose. The rate was significantly higher among nonpregnant comparators (dose 1: relative risk [RR] 0.94, 95% confidence interval [CI] 0.93-0.94; dose 2: RR 0.91, 95% CI 0.90-0.91). However, the rate of SARS-CoV-2 vaccination uptake among birthing people was higher than uptake of Tdap or influenza vaccination. Tetanus, diphtheria, and pertussis vaccination increased over time from 22.2% in 2019 to 32.6% in 2022, and influenza vaccination rose to 35.3% in 2021 but returned to prepandemic levels in 2022 (27.7%). Vaccination rates were lower among pregnant people who were young, multiparous, or residents of rural or economically deprived areas for all 3 vaccines.

interpretationRates of SARS-CoV-2 vaccination were lower among pregnant people than among nonpregnant comparators but were higher than rates of routinely recommended Tdap and influenza vaccinations. Pandemic urgency may have overcome a great deal of hesitancy about vaccinating against SARS-CoV-2 during pregnancy in 2022, but uptake of routinely recommended vaccines in pregnancy remains a challenge.

trial registrationClinicaltrials.gov, no. NCT05663762.

Indexed as

COVID-19Diphtheria-Tetanus-acellular Pertussis VaccinesInfluenza, HumanInfluenza VaccinesAdultCOVID-19 VaccinesFemaleHumansOntarioPregnancyPregnancy Complications, InfectiousRetrospective StudiesSARS-CoV-2VaccinationYoung AdultCOVID-19 VaccinesDiphtheria-Tetanus-acellular Pertussis VaccinesInfluenza Vaccines

Identifiers

PMID39353631
PMCPMC11444691

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.