Evidence map›Paper›PMID 39353419›Full record

ArticleThe American journal of tropical medicine and hygiene2024

Correlation of Clinical Severity of Trachomatous Inflammation and Chlamydia trachomatis Bacterial Load.

Louisa Lu, Ali Fauci, Quintin R Richardson, Hamidah Mahmud, John M Nesemann, Solomon Aragie, Dagnachew Hailu, Adane Dagnew, Ambahun Chernet, Zerihun Tadesse and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Pathogens (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Louisa LuFrancis I. Proctor Foundation, University of California, San Francisco, California.
Ali FauciFrancis I. Proctor Foundation, University of California, San Francisco, California.
Quintin R RichardsonFrancis I. Proctor Foundation, University of California, San Francisco, California.
Hamidah MahmudFrancis I. Proctor Foundation, University of California, San Francisco, California.
John M NesemannFrancis I. Proctor Foundation, University of California, San Francisco, California.
Solomon AragieThe Carter Center Ethiopia, Addis Ababa, Ethiopia.
Dagnachew HailuThe Carter Center Ethiopia, Addis Ababa, Ethiopia.
Adane DagnewThe Carter Center Ethiopia, Addis Ababa, Ethiopia.
Ambahun ChernetThe Carter Center Ethiopia, Addis Ababa, Ethiopia.
Zerihun TadesseThe Carter Center Ethiopia, Addis Ababa, Ethiopia.
Taye ZeruAmhara Public Health Institute, Bahir Dar, Ethiopia.
Isabel J B ThompsonFrancis I. Proctor Foundation, University of California, San Francisco, California.
Dionna M WittbergFrancis I. Proctor Foundation, University of California, San Francisco, California.
Scott D NashThe Carter Center, Atlanta, Georgia.
Thomas M LietmanFrancis I. Proctor Foundation, University of California, San Francisco, California.
Jeremy D KeenanFrancis I. Proctor Foundation, University of California, San Francisco, California.

Funding

Sanitation, Water, and Instruction in Face-washing for TrachomaU10EY023939 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KEENAN, JEREMY DAVID · 2014 to 2018
$2.7M
NEI NIH HHS U10 EY023939
6 · The paper itself

Abstract

The purpose of this study was to investigate the correlation between bacterial load of Chlamydia trachomatis as measured from quantitative polymerase chain reaction (qPCR) and the relative clinical severity of trachomatous inflammation. Individuals with trachoma from rural communities in Ethiopia had photographs taken as well as swabs obtained of the upper tarsal conjunctivas. Conjunctival swabs were processed with PCR assay, which provided quantitative results of ocular chlamydial load. A series of 125 conjunctival photographs were ranked from least to most severe according to clinical severity for follicular and papillary conjunctivitis. Higher intensity rankings of trachomatous inflammation were associated with higher chlamydial load for both follicular inflammation (Spearman's ρ = 0.43; P <0.001) and papillary inflammation (Spearman's ρ = 0.50; P <0.001). Rankings of trachomatous inflammation may be a clinically meaningful indicator of trachoma.

Indexed as

Bacterial LoadChlamydia trachomatisTrachomaAdolescentAdultChildChild, PreschoolConjunctivaEthiopiaFemaleHumansInflammationMaleMiddle AgedSeverity of Illness IndexYoung Adult

Identifiers

PMID39353419
PMCPMC11619492

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.