Evidence map›Paper›PMID 39353246›Full record

ArticleJournal of biomechanics2024

Synovial fluid does not retard fluid exudation during stress-relaxation of immature bovine cartilage.

C V Sise, C A Petersen, J Yun, S Vukelic, C T Hung, G A Ateshian

Abstract read
In one paragraph

Article in Journal of biomechanics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

C V SiseDepartment of Biomedical Engineering, Columbia University, New York, NY, United States.
C A PetersenDepartment of Mechanical Engineering, Columbia University, New York, NY, United States.
J YunDepartment of Biomedical Engineering, Columbia University, New York, NY, United States.
S VukelicDepartment of Mechanical Engineering, Columbia University, New York, NY, United States.
C T HungDepartment of Biomedical Engineering, Columbia University, New York, NY, United States.
G A AteshianDepartment of Biomedical Engineering, Columbia University, New York, NY, United States; Department of Mechanical Engineering, Columbia University, New York, NY, United States. Electronic address: ateshian@columbia.edu.

Funding

Laser Treatment Modality for Strengthening Osteoarthritic CartilageR01AR073289 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ATESHIAN, GERARD A., VUKELIC, SINISA · 2019 to 2022
$1.2M
NIAMS NIH HHS R01 AR073289
6 · The paper itself

Abstract

Interstitial fluid load support (FLS) is a dominant mechanism of lubrication in cartilage, producing a low friction coefficient while enhancing the tissue's load bearing capabilities. Due to its viscosity, synovial fluid (SF) may retard loss of FLS by slowing the exudation of interstitial fluid from the cartilage. This study tested this hypothesis by comparing the stress-relaxation (SRL) response of immature bovine articular cartilage immersed either in phosphate buffered saline (PBS) or in healthy mature bovine SF, under unconfined compression (fluid exudation across cut lateral tissue boundary) and indentation testing (fluid exudation across articular surface). To investigate the influence of diffusion of SF molecular constituents into cartilage, the effect of incubation time in SF on SRL was also investigated. The SRL response in unconfined compression was not significantly different in PBS versus SF when compared directly (p = 0.98) and had a slope ofm = 1.00 ± 0.04 (R

Indexed as

Cartilage, ArticularSynovial FluidAnimalsCattleExtracellular FluidStress, MechanicalViscosityWeight-BearingCartilageInterstitial Fluid PressurizationOsteoarthritisStress-relaxationSynovial Fluid

Identifiers

PMID39353246
PMCPMC11560560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.