Evidence map›Paper›PMID 39353038›Full record

ArticleScience signaling2024

Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice.

Haichang Luo, Ezequiel Marron Fernandez de Velasco, Benjamin Gansemer, McKinzie Frederick, Carolina Aguado, Rafael Luján, Stanley A Thayer, Kevin Wickman

Abstract read
In one paragraph

Article in Science signaling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haichang LuoDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-5120-9232
Ezequiel Marron Fernandez de VelascoDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
Benjamin GansemerDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-7506-8972
McKinzie FrederickDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
Carolina AguadoSynaptic Structure Laboratory, Departmento de Ciencias Médicas, Instituto de Biomedicina, Facultad de Medicina, Universidad de Castilla-La Mancha, Campus Biosanitario, Albacete 02006, Spain.ORCID 0000-0003-0265-8124
Rafael LujánSynaptic Structure Laboratory, Departmento de Ciencias Médicas, Instituto de Biomedicina, Facultad de Medicina, Universidad de Castilla-La Mancha, Campus Biosanitario, Albacete 02006, Spain.ORCID 0000-0003-2001-9545
Stanley A ThayerDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-0856-6522
Kevin WickmanDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-5179-9540

Funding

Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI Mark John Thomas · 2020 to 2026
$19.0M
HIV NEUROTOXICITY--MECHANISM &MODULATION BY CANABINOIDSR01DA007304 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THAYER, STANLEY A · 1992 to 2024
$5.0M
HIV Neurotoxicity-Mechanism &Modulation by CannabinoidsR37DA007304 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI THAYER, STANLEY A · 2004 to 2013
$3.1M
RESEARCH TRAINING IN DRUG ABUSE BEHAVIORT32DA007304 · NIDA · UNIVERSITY OF KENTUCKY · PI RUSH, CRAIG R · 1998 to 2012
$3.1M
Architecture of inhibitory G protein signaling in the hippocampusR01NS128039 · NINDS · UNIVERSITY OF MINNESOTA · PI Kirill A. Martemyanov, KEVIN D WICKMAN · 2023 to 2026
$2.6M
Alcohol-related suppression of GIRK channel activity in the basal amygdala: a link to plasticity of glutamatergic neurotransmission and withdrawal-associated behavior?R01AA027544 · NIAAA · UNIVERSITY OF MINNESOTA · PI WICKMAN, KEVIN D · 2020 to 2024
$1.7M
NIAAA NIH HHS R01 AA027544NIDA NIH HHS P30 DA048742NIDA NIH HHS R01 DA007304NIDA NIH HHS R37 DA007304NIDA NIH HHS T32 DA007304NINDS NIH HHS R01 NS128039
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by amyloid plaques and cognitive decline, the latter of which is thought to be driven by soluble oligomeric amyloid-β (oAβ). The dysregulation of G protein-gated inwardly rectifying K

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHippocampusAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, TransgenicNeuronsPeptide FragmentsPhospholipases A2Receptor, Metabotropic Glutamate 5Amyloid beta-Peptidesamyloid beta-protein (1-42)G Protein-Coupled Inwardly-Rectifying Potassium ChannelsPeptide FragmentsPhospholipases A2Receptor, Metabotropic Glutamate 5

Identifiers

PMID39353038
PMCPMC11600338

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.