Evidence map›Paper›PMID 39352879›Full record

ArticleACS infectious diseases2024

Repositioning Brusatol as a Transmission Blocker of Malaria Parasites.

Amelia Cox, Neelima Krishnankutty, Steven Shave, Virginia M Howick, Manfred Auer, James J La Clair, Nisha Philip

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amelia CoxSchool of Biodiversity, One Health and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, United Kingdom.
Neelima KrishnankuttyInstitute of Immunology and Infection Research, University of Edinburgh, Ashworth Laboratories 2, Room 3.11, Edinburgh EH9 3FL, United Kingdom.
Steven ShaveSchool of Biological Sciences, University of Edinburgh, The King's Buildings, Edinburgh EH9 3BF, United Kingdom.ORCID 0000-0001-6996-3663
Virginia M HowickSchool of Biodiversity, One Health and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, United Kingdom.
Manfred AuerSchool of Biological Sciences, University of Edinburgh, The King's Buildings, Edinburgh EH9 3BF, United Kingdom.ORCID 0000-0001-8920-3522
James J La ClairXenobe Research Institute, P.O. Box 3052, San Diego, California 92163, United States.ORCID 0000-0001-6500-4107
Nisha PhilipInstitute of Immunology and Infection Research, University of Edinburgh, Ashworth Laboratories 2, Room 3.11, Edinburgh EH9 3FL, United Kingdom.

Funding

Wellcome TrustWellcome Trust 201531/Z/16/ZWellcome Trust 212398/Z/18/ZWellcome Trust 220185/Z/20/Z
6 · The paper itself

Abstract

Currently, primaquine is the only malaria transmission-blocking drug recommended by the WHO. Recent efforts have highlighted the importance of discovering new agents that regulate malarial transmission, with particular interest in agents that can be administered in a single low dose, ideally with a discrete and

Indexed as

AntimalarialsMalariaQuassinsAnimalsDrug RepositioningHumansMicePlasmodiumPlasmodium falciparumAntimalarialsbrusatolQuassinsbrusatoldrug discoverymalarianatural productsquassinoidstransmission blocking

Identifiers

PMID39352879
PMCPMC11474950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.