Evidence map›Paper›PMID 39352775›Full record

Trial reportEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2024

The efficacy of loco-regional ropivacaine analgesia via intercostal catheters after lung resection: a randomized, double-blind, placebo-controlled, superiority study.

Aljaz Hojski, Monica Krämer, Paulius Gecas, Zeljko Djakovic, Nikolay Tsvetkov, Makhmudbek Mallaev, Daniel Bolliger, Andreas Lampart, Didier Lardinois

Registry-linked trialAbstract readRandomized Controlled TrialEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04939545 (Efficacy of Surgically Placed Intercostal Catheter), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04939545 phase3completednot on this map

Efficacy of Surgically Placed Intercostal Catheter (ICC) for Postoperative Analgesia After Minimally Invasive Anatomical Lung Resection Using Ropivacaine: A Randomised, Double-blind, Placebocontrolled, Superiority Study

TypeinterventionalSponsorUniversity Hospital, Basel, SwitzerlandRan2021 to 2023Enrolled32ConditionsPostoperative AnalgesiaArmsRopivacain, NaCl 0.9%
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aljaz HojskiDepartment of Thoracic Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0002-6313-1257
Monica KrämerDepartment of Thoracic Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Paulius GecasDepartment of Thoracic Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Zeljko DjakovicDepartment of Thoracic Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Nikolay TsvetkovDepartment of Thoracic Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Makhmudbek MallaevDepartment of Thoracic Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Daniel BolligerClinic for Anesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, University of Basel, Basel, Switzerland.
Andreas LampartClinic for Anesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel, University of Basel, Basel, Switzerland.
Didier LardinoisDepartment of Thoracic Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.

Funding

Forschungsstiftung University Hospital Basel
6 · The paper itself

Abstract

objectivesPostoperative pain remains a burden for patients after minimally invasive anatomic lung resection. Current guidelines recommend the intraoperative placement of intercostal catheters to promote faster recovery. This trial aimed to determine the analgesic efficacy of continuous loco-regional ropivacaine application via intercostal catheter and establish this method as a possible standard of care.

methodsBetween December 2021 and October 2023, patients were randomly assigned to receive ropivacaine 0.2% or a placebo through an intercostal catheter with a flow rate of 6-8 ml/h for 72 h after surgery. Patients were undergoing anatomic VATS lung resection under general anaesthesia for confirmed or suspected stage I lung cancer (UICC, 8th edition). The sample size was calculated to assess a difference in numerical rating scale associated with pain reduction of 1.5 points.

resultsFourteen patients were included in the ropivacaine group, whereas the placebo group comprised 18 participants. Patient characteristics and preoperative pain scores were similar in both groups. There was no statistically significant difference in postoperative pain scores and morphine consumption between the 2 groups. The mean numerical rating scale when coughing during the first 24 h postoperatively was 4.9 (SD: 2.2) in the ropivacaine group and 4.3 (SD: 2.4); P = 0.47 in the placebo group. We were unable to determine any effect of administered ropivacaine on the postoperative pulmonary function (FEV1, PEF).

conclusionsOur preliminary results suggest that continuous loco-regional ropivacaine administration via surgically placed intercostal catheter has no positive effect on postoperative pain scores or morphine requirements. CLINICAL REGISTRATION NUMBER: NCT04939545.

Indexed as

Anesthetics, LocalPneumonectomyPostoperative PainRopivacaineAgedAnalgesiaCathetersDouble-Blind MethodFemaleHumansIntercostal NervesLung NeoplasmsMaleMiddle AgedPain MeasurementTreatment OutcomeAnesthetics, LocalRopivacaineIntercostal catheterMinimally invasive lung surgeryRegional anaesthesiaVideo-assisted thoracoscopic surgery

Identifiers

PMID39352775
PMCPMC11470208

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.