Evidence map›Paper›PMID 39352671›Full record

ArticleBulletin of experimental biology and medicine2024

Expression of Types I and III Collagens and Ultrastructure of the Extracellular Matrix in Rectal Adenocarcinoma of Different Differentiation Degree after Neoadjuvant Radiation Therapy.

N P Bgatova, N E Skudin, M A Karpov, Yu S Taskaeva, M E Ryaguzov, A I Lomakin, S A Fursov, M A Korolev

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

N P BgatovaFederal Research Center Institute of Cytology and Genetics, Research Institute of Clinical and Experimental Lymphology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. nataliya.bgatova@yandex.ru.
N E SkudinNovosibirsk Regional Clinical Oncology Dispensary, Novosibirsk, Russia.
M A KarpovFederal Research Center Institute of Cytology and Genetics, Research Institute of Clinical and Experimental Lymphology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Yu S TaskaevaFederal Research Center Institute of Cytology and Genetics, Research Institute of Clinical and Experimental Lymphology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
M E RyaguzovNovosibirsk Regional Clinical Oncology Dispensary, Novosibirsk, Russia.
A I LomakinNovosibirsk Regional Clinical Oncology Dispensary, Novosibirsk, Russia.
S A FursovNovosibirsk Regional Clinical Oncology Dispensary, Novosibirsk, Russia.
M A KorolevFederal Research Center Institute of Cytology and Genetics, Research Institute of Clinical and Experimental Lymphology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The structural organization of the extracellular matrix of rectal adenocarcinoma of different differentiation degrees without and after neoadjuvant radiation therapy was studied on postoperative material using immunohistochemistry and electron microscopy. The differences in the expression of types I and III collagens, as well as in the ultrastructural organization of the extracellular matrix of rectal adenocarcinoma of different differentiation degrees without and after neoadjuvant radiation therapy were revealed. We observed high expression of collagen I and wide channels in the collagen matrix in the central areas of the well differentiated adenocarcinomas without neoadjuvant radiation therapy and in poorly differentiated adenocarcinomas after neoadjuvant radiation therapy, which can be associated with metastasis and poor prognosis for the patients.

Indexed as

AdenocarcinomaCollagen Type ICollagen Type IIIExtracellular MatrixNeoadjuvant TherapyRectal NeoplasmsAgedFemaleHumansImmunohistochemistryMaleMiddle AgedCollagen Type ICollagen Type IIIcollagensdifferentiation degreeneoadjuvant radiation therapyrectal adenocarcinomaultrastructure

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.