Evidence map›Paper›PMID 39352287›Full record

ArticleRadiology2024

Four-dimensional Flow MRI-based Computational Fluid Dynamics Simulation for Noninvasive Portosystemic Pressure Gradient Assessment in Patients with Cirrhosis and Transjugular Intrahepatic Portosystemic Shunt.

Christoph Riedel, Marko Hoffmann, Muhammad Ismahil, Alexander Lenz, Felix Piecha, Inka Ristow, Johannes Kluwe, Michael Schlüter, Gerhard Adam, Bjoern P Schoennagel and 2 more

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Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Christoph RiedelFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).ORCID 0000-0001-8342-296X
Marko HoffmannFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).
Muhammad IsmahilFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).
Alexander LenzFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).ORCID 0000-0003-1916-1317
Felix PiechaFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).
Inka RistowFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).ORCID 0000-0002-3032-2321
Johannes KluweFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).
Michael SchlüterFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).
Gerhard AdamFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).ORCID 0000-0001-7976-3868
Bjoern P SchoennagelFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).
Scott B ReederFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).ORCID 0000-0003-4728-8171
Peter BannasFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine (C.R., A.L., I.R., G.A., B.P.S., P.B.) and I. Department of Medicine (F.P., J.K.), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; Institute of Multiphase Flows, Hamburg University of Technology, Hamburg, Germany (M.H., M.I., M.S.); and Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, Wis (S.B.R.).

Funding

Development of 4D Flow MRI for Risk Stratification of Variceal Bleeding in CirrhosisR01DK125783 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., WIEBEN, OLIVER · 2021 to 2024
$2.2M
Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRIR01DK083380 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2010 to 2013
$1.2M
NIDDK NIH HHS R01 DK083380NIDDK NIH HHS R01 DK125783
6 · The paper itself

Abstract

Background Transjugular intrahepatic portosystemic shunt (TIPS) dysfunction in patients with liver cirrhosis and recurrent symptoms of portal hypertension is primarily assessed with US and confirmed with invasive catheter venography, which can be used to measure the portosystemic pressure gradient (PSPG) to identify TIPS-refractory portal hypertension. To avoid the risks and costs of invasive catheter venography, noninvasive PSPG evaluation strategies are needed. Purpose To demonstrate the feasibility of the combination of four-dimensional (4D) flow MRI with computational fluid dynamics (CFD) for noninvasive PSPG assessment in participants with cirrhosis and TIPS. Materials and Methods Abdominal 4D flow MRI was performed prospectively in participants with cirrhosis and TIPS between January 2019 and September 2020. Flow rates were measured within the TIPS and inferior vena cava (IVC). The portal vein (PV), TIPS, right hepatic vein, and IVC were segmented on MRI scans to create a CFD mesh. The PV and infrahepatic IVC were defined as inflows for 4D flow MRI-derived flow rates. The suprahepatic IVC was defined as the outflow. CFD simulations were used to noninvasively estimate PSPG as the difference between the simulated pressures in the PV and suprahepatic IVC. Invasive venographic measurements of the PSPG served as the reference standard, and Pearson correlation analysis was conducted to evaluate the relationship between noninvasive estimates and invasive measurements. Results In all 20 participants with cirrhosis (mean age, 58 years ± 9 [SD]; 11 men), 4D flow MRI-based CFD simulations enabled visualization of flow velocities and pressure distributions within the segmented vasculature and TIPS. Noninvasive estimates and invasive measures of PSPG were strongly correlated (

Indexed as

HydrodynamicsHypertension, PortalLiver CirrhosisMagnetic Resonance ImagingPortasystemic Shunt, Transjugular IntrahepaticAgedComputer SimulationFeasibility StudiesFemaleHumansMaleMiddle AgedProspective Studies

Identifiers

PMID39352287
PMCPMC11535865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.