Evidence map›Paper›PMID 39352115›Full record

ArticleNeuropsychopharmacology reports2024

Potential differences in receptor-mediated G-protein activation in postmortem human hippocampal membranes prepared from healthy controls and suicide victims.

Yuji Odagaki, Masakazu Kinoshita, Miklós Palkovits, Dasiel Oscar Borroto-Escuela, Kjell Fuxe

Abstract read
In one paragraph

Article in Neuropsychopharmacology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuji OdagakiDepartment of Psychiatry, Faculty of Medicine, Saitama Medical University, Saitama, Japan.ORCID 0000-0002-1792-028X
Masakazu KinoshitaDepartment of Psychiatry, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
Miklós PalkovitsHuman Brain Tissue Bank, Semmelweis University, Budapest, Hungary.ORCID 0000-0003-0578-0387
Dasiel Oscar Borroto-EscuelaDepartment of Neuroscience, Biomedicum, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-5736-373X
Kjell FuxeDepartment of Neuroscience, Biomedicum, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0001-8491-4288

Funding

European Commission under the Sixth Framework ProgrammeSaitama Medical UniversityStiftelsen Olle Engkvist Byggmästare 2021
6 · The paper itself

Abstract

aimPostmortem brain studies offer enormous opportunities to study molecular mechanisms associated with suicide. In the present study, conventional [

methodsBy using conventional [

resultsNo significant differences in pharmacological parameters of all concentration-response curves investigated were found between suicide victims and control subjects. Significant correlations were obtained for the maximal percent increases between some distinct signaling pathways.

conclusionAlthough only preliminary and auxiliary results were obtained as to the potential differences between suicide victims and control subjects because of the limited number of subjects as well as unmatched age and postmortem delay, adenosine A

Indexed as

HippocampusSuicideAdultAgedFemaleGTP-Binding ProteinsGuanosine 5'-O-(3-Thiotriphosphate)HumansMaleMiddle AgedReceptors, G-Protein-CoupledYoung AdultGTP-Binding ProteinsGuanosine 5'-O-(3-Thiotriphosphate)Receptors, G-Protein-Coupled[35S]GTPγS bindingG‐proteinhuman hippocampuspostmortem brain studysuicide

Identifiers

PMID39352115
PMCPMC11609751

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.