Evidence map›Paper›PMID 39352071›Full record

ArticleAdvanced healthcare materials2024

A Robust ROS Generation and Ferroptotic Lipid Modulation Nanosystem for Mutual Reinforcement of Ferroptosis and Cancer Immunotherapy.

Chao Jiang, Wenxi Li, Jie Yan, Xinying Yu, Yuzhao Feng, Bei Li, Yuan Liu, Yunlu Dai

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chao JiangCancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China.
Wenxi LiCancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China.
Jie YanCancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China.
Xinying YuCancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China.
Yuzhao FengCancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China.
Bei LiCancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China.
Yuan LiuZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
Yunlu DaiCancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China.ORCID 0000-0003-4023-7320

Funding

Guangdong Basic and Applied Basic Research Foundation 2024A1515011140Ministry of Education Frontiers Science Centre for Precision Oncology, University of Macau SP2023-00001-FSCPONational Natural Science Foundation of China 32101069National Natural Science Foundation of China 32171318National Natural Science Foundation of China NSFC 32222090Natural Science Foundation of Zhejiang Province YXD24B0402Research Services and Knowledge Transfer Office, University of Macau MYRG2022-00011-FHSResearch Services and Knowledge Transfer Office, University of Macau MYRG-GRG2023-00013-FHS-UMDFScience and Technology Development Fund, Macau SAR 0002/2021/AKPScience and Technology Development Fund, Macau SAR 0006/2023/ITP1Science and Technology Development Fund, Macau SAR 0009/2022/AKPScience and Technology Development Fund, Macau SAR 0103/2021/AScience and Technology Development Fund, Macau SAR 0133/2022/A3
6 · The paper itself

Abstract

Ferroptosis initiation is often utilized for synergistic immunotherapy. While, current immunotherapy is limited by an immunosuppressive tumor microenvironment (TME), and ferroptosis is limited by insufficient reactive oxygen species (ROS) and ferroptotic lipids in tumor cells. Here, an arachidonic acid (AA) loaded nanosystem (CTFAP) is developed to mutually reinforce ferroptosis and cancer immunotherapy by augmenting ROS generation and modulating ferroptotic lipids. CTFAP is composed of acid-responsive core calcium peroxide (CaO

Indexed as

FerroptosisImmunotherapyNanoparticlesReactive Oxygen SpeciesAnimalsArachidonic AcidCell Line, TumorFemaleHumansHydrogen PeroxideLipid PeroxidationMetal-Organic FrameworksMiceNeoplasmsPeroxidesTumor MicroenvironmentArachidonic Acidcalcium peroxideHydrogen PeroxideMetal-Organic FrameworksPeroxidesReactive Oxygen Speciescancer immunotherapyferroptosisferroptotic lipidsimmunogenic cell deathreactive oxygen species

Identifiers

PMID39352071
PMCPMC11616257

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.