Evidence map›Paper›PMID 39352036›Full record

ArticlePediatrics2024

Effects of Blood Lead Levels <10 µg/dL in School-Age Children and Adolescents: A Scoping Review.

Audrey F Pennington, Madison R Smith, Stella O Chuke, Cheryl R Cornwell, Paul B Allwood, Joseph G Courtney

Abstract readScoping Review
In one paragraph

Article in Pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Audrey F PenningtonLead Poisoning Prevention and Surveillance Branch, Division of Environmental Health Science and Practice, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta.
Madison R SmithLead Poisoning Prevention and Surveillance Branch, Division of Environmental Health Science and Practice, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta.
Stella O ChukeLead Poisoning Prevention and Surveillance Branch, Division of Environmental Health Science and Practice, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta.
Cheryl R CornwellLead Poisoning Prevention and Surveillance Branch, Division of Environmental Health Science and Practice, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta.
Paul B AllwoodLead Poisoning Prevention and Surveillance Branch, Division of Environmental Health Science and Practice, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta.
Joseph G CourtneyLead Poisoning Prevention and Surveillance Branch, Division of Environmental Health Science and Practice, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

contextLead exposures among school-age children are a major public health issue. Although the harmful effects of lead exposure during the first years of life are well known, there is not as much understanding of the effects of low levels of lead exposure during later childhood.

objectivesTo review the effects of blood lead levels (BLLs) <10 µg/dL in school-age children and adolescents. DATA SOURCES: We searched Medline, Embase, Global health, CINAHL, Scopus, and Environmental Science Collection databases between January 1, 2000, and May 11, 2023. STUDY SELECTION: We included peer-reviewed English-language articles that presented data on the effects of BLLs <10 µg/dL in individuals ages 5 through 18 years. DATA EXTRACTION: Data on country, population, analytic design, sample size, age, BLLs, outcomes, covariates, and results were extracted.

resultsOverall, 115 of 3180 screened articles met the inclusion criteria. The reported mean or median BLL was <5 µg/dL in 98 articles (85%). Of the included articles, 89 (77%) presented some evidence of an association between BLLs <10 µg/dL during school age and detrimental outcomes in a wide range of categories. The strongest evidence of an association was for the outcomes of intelligence quotient and attention-deficit/hyperactivity disorder diagnoses or behaviors. LIMITATIONS: Few articles controlled for BLLs at age <5 years, limiting conclusions about the relation between later BLLs and outcomes.

conclusionsBLLs <10 µg/dL in school-age children and adolescents may be associated with negative outcomes. This review highlights areas that could benefit from additional investigation.

Indexed as

LeadAdolescentChildChild, PreschoolEnvironmental ExposureHumansLead PoisoningLead

Identifiers

PMID39352036
PMCPMC11610497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.