Evidence map›Paper›PMID 39351703›Full record

ArticleClinical oral implants research2025

Horizontal Guided Bone Regeneration of the Posterior Mandible to Allow Implant Placement: 1-Year Prospective Study Results.

Jonas Lorenz, Shahram Ghanaati, Zoran Aleksic, Iva Milinkovic, Zoran Lazic, Marko Magić, Bastian Wessing, Ramona Schleich Grotenclos, Mauro Merli, Giorgia Mariotti and 3 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in Clinical oral implants research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03028922 (A Prospective, Multi-centre Study Evaluating Creos™ Xenogain Bone Graft Substitute in Horizontal Ridge Augmentation in the Premolar and Molar Region of the Mandible), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03028922 naunknown statusnot on this map

A Prospective, Multi-centre Study Evaluating Creos™ Xenogain Bone Graft Substitute in Horizontal Ridge Augmentation in the Premolar and Molar Region of the Mandible

TypeinterventionalSponsorNobel BiocareRan2016 to 2020Enrolled42ConditionsHorizontal Bone AugmentationArmscreos xenogain
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jonas LorenzFORM-Frankfurt Orofacial Regenerative Medicine, Clinic for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID 0000-0002-4209-3992
Shahram GhanaatiFORM-Frankfurt Orofacial Regenerative Medicine, Clinic for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID 0000-0002-7897-0854
Zoran AleksicDepartment of Periodontology and Oral Medicine, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.ORCID 0000-0003-0390-8789
Iva MilinkovicDepartment of Periodontology and Oral Medicine, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.ORCID 0000-0001-5664-7848
Zoran LazicDepartment of Implantology, Medical Military Academy, Belgrade, Serbia.
Marko MagićSchool of Dental Medicine, University of Belgrade, Belgrade, Serbia.ORCID 0000-0003-1526-5928
Bastian WessingPraxisklinik der Zahnheilkunde am Luisenhospital, Aachen, Germany.ORCID 0000-0003-3703-5744
Ramona Schleich GrotenclosPraxisklinik der Zahnheilkunde am Luisenhospital, Aachen, Germany.
Mauro MerliClinica Merli, Rimini, Italy.
Giorgia MariottiClinica Merli, Rimini, Italy.
Eriberto BressanDepartment of Neurosciences, School of Dentistry, University of Padova, Padova, Italy.ORCID 0000-0003-4698-8598
Luca De StavolaDepartment of Neurosciences, School of Dentistry, University of Padova, Padova, Italy.ORCID 0000-0001-6270-5143
Robert SaderFORM-Frankfurt Orofacial Regenerative Medicine, Clinic for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID 0000-0002-0265-0301

Funding

Nobel Biocare Services AG (grant number T-189)
6 · The paper itself

Abstract

objectiveAssess whether horizontal ridge augmentation with guided bone regeneration (GBR) using deproteinized bovine bone mineral (DBBM), autologous bone, and a resorbable collagen membrane supports successful implant placement. MATERIALS AND

methodsThis open, prospective, single-cohort, multicenter clinical study included patients with ridge defects that required GBR prior to implant insertion. The primary endpoint was radiologically assessed bone gain after 8 months post-GBR, measured at the center of planned implant sites. Secondary endpoints included implant survival and success, marginal bone levels (MBLs), MBL changes, and soft tissue health.

resultsOf 45 patients evaluated 8 months post-GBR, nine experienced dehiscence in the first 3 weeks of the healing period. GBR led to radiologically determined mean bone width gain of 4.0 ± 1.5 mm and 4.8 ± 1.7 mm, measured 1 and 3 mm from the top of the crest, respectively, allowing successful implant placement in 44 patients (97.8%). The cumulative implant survival and success rates were 98.9% and 95.5%, respectively. MBLs were stable: -1.18 ± 0.64 mm at definitive prosthesis placement (DPP) and - 1.07 ± 0.74 mm at 1 year. Soft tissue health and esthetics (plaque and bleeding indices, papilla, keratinized mucosa, and pink esthetic score) improved from DPP to 1 year. Patients were highly satisfied with implant function and esthetics, and their oral health-related quality of life improved.

conclusionsGBR using DBBM and a collagen membrane offered a safe and effective treatment option for horizontal ridge augmentation sufficient to support implant-based tooth rehabilitation.

trial registrationRegistered at ClinicalTrials.gov NCT03028922 (registrations sites, as above listed affiliations, first posted January 23, 2017).

Indexed as

Alveolar Ridge AugmentationBone RegenerationGuided Tissue Regeneration, PeriodontalMandibleAdultAgedDental Implantation, EndosseousFemaleHumansMaleMiddle AgedProspective StudiesTreatment Outcomealveolar ridge augmentationbone regenerationbone substitutesdental implanttorquexenograft

Identifiers

PMID39351703
PMCPMC11701953

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.