Evidence map›Paper›PMID 39351650›Full record

ArticleJournal of cellular and molecular medicine2024

The enhancing effects of selenomethionine on harmine in attenuating pathological cardiac hypertrophy via glycolysis metabolism.

Qi Chen, Wen-Yan Wang, Qing-Yang Xu, Yan-Fa Dai, Xing-Yu Zhu, Zhao-Yang Chen, Ning Sun, Chung-Hang Leung, Fei Gao, Ke-Jia Wu

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. High-throughput screening of EGFR/CaJournal of pharmaceutical analysis · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qi ChenWuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, P. R. China.
Wen-Yan WangWuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, P. R. China.
Qing-Yang XuWuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, P. R. China.
Yan-Fa DaiWuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, P. R. China.
Xing-Yu ZhuWuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, P. R. China.
Zhao-Yang ChenDepartment of Cardiology, Heart Center of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, Fujian, P. R. China.
Ning SunWuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, P. R. China.
Chung-Hang LeungState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, P. R. China.ORCID 0000-0003-2988-3786
Fei GaoDepartment of cardiology, Beijing An Zhen Hospital, Capital Medical University, Chaoyang, Beijing, P. R. China.
Ke-Jia WuWuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, P. R. China.ORCID 0000-0002-0809-5628

Funding

Fundamental Research Funds for the Central Universities 22520231069National Natural Science Foundation of China 82200403National Natural Science Foundation of China 82470364Postgraduate Research & Practice Innovation of Jiangsu Province KYCX24_2646
6 · The paper itself

Abstract

Pathological cardiac hypertrophy, a common feature in various cardiovascular diseases, can be more effectively managed through combination therapies using natural compounds. Harmine, a β-carboline alkaloid found in plants, possesses numerous pharmacological functions, including alleviating cardiac hypertrophy. Similarly, Selenomethionine (SE), a primary organic selenium source, has been shown to mitigate cardiac autophagy and alleviate injury. To explores the therapeutic potential of combining Harmine with SE to treat cardiac hypertrophy. The synergistic effects of SE and harmine against cardiac hypertrophy were assessed in vitro with angiotensin II (AngII)-induced hypertrophy and in vivo using a Myh6

Indexed as

CardiomegalyGlycolysisHarmineSelenomethionineAngiotensin IIAnimalsDisease Models, AnimalDrug SynergismMaleMiceMice, Inbred C57BLMyocytes, CardiacSignal TransductionAngiotensin IIHarmineSelenomethioninecardiac hypertrophycombination therapyglycolysis metabolismharmineselenomethionine

Identifiers

PMID39351650
PMCPMC11443162

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.