Evidence map›Paper›PMID 39351536›Full record

ArticleFrontiers in endocrinology2024

Impact of Hashimoto's thyroiditis on the tumor microenvironment in papillary thyroid cancer: insights from single-cell analysis.

Hongzhe Ma, Guoqi Li, Diwei Huo, Yangguang Su, Qing Jin, Yangxu Lu, Yanyan Sun, Denan Zhang, Xiujie Chen

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongzhe Ma *Department of Pharmacogenomics, College of Bioinformatics and Science Technology, Harbin Medical University, Harbin, China.
Guoqi Li *Department of Pharmacogenomics, College of Bioinformatics and Science Technology, Harbin Medical University, Harbin, China.
Diwei Huo *Department of Urology Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Yangguang SuDepartment of Pharmacogenomics, College of Bioinformatics and Science Technology, Harbin Medical University, Harbin, China.
Qing JinDepartment of Pharmacogenomics, College of Bioinformatics and Science Technology, Harbin Medical University, Harbin, China.
Yangxu LuDepartment of Pharmacogenomics, College of Bioinformatics and Science Technology, Harbin Medical University, Harbin, China.
Yanyan SunDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Denan ZhangDepartment of Pharmacogenomics, College of Bioinformatics and Science Technology, Harbin Medical University, Harbin, China.
Xiujie ChenDepartment of Pharmacogenomics, College of Bioinformatics and Science Technology, Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the impact of Hashimoto's thyroiditis (HT), an autoimmune disorder, on the papillary thyroid cancer (PTC) microenvironment using a dataset of 140,456 cells from 11 patients. By comparing PTC cases with and without HT, we identify HT-specific cell populations (HASCs) and their role in creating a TSH-suppressive environment via mTE3, nTE0, and nTE2 thyroid cells. These cells facilitate intricate immune-stromal communication through the MIF-(CD74+CXCR4) axis, emphasizing immune regulation in the TSH context. In the realm of personalized medicine, our HASC-focused analysis within the TCGA-THCA dataset validates the utility of HASC profiling for guiding tailored therapies. Moreover, we introduce a novel, objective method to determine K-means clustering coefficients in copy number variation inference from bulk RNA-seq data, mitigating the arbitrariness in conventional coefficient selection. Collectively, our research presents a detailed single-cell atlas illustrating HT-PTC interactions, deepening our understanding of HT's modulatory effects on PTC microenvironments. It contributes to our understanding of autoimmunity-carcinogenesis dynamics and charts a course for discovering new therapeutic targets in PTC, advancing cancer genomics and immunotherapy research.

Indexed as

Hashimoto DiseaseSingle-Cell AnalysisThyroid Cancer, PapillaryThyroid NeoplasmsTumor MicroenvironmentFemaleHumansMalecancer genomicsimmune cell communicationsingle-cell analysisTCGA-THCAthyroid-stimulating hormone

Identifiers

PMID39351536
PMCPMC11439672

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.