Evidence map›Paper›PMID 39351327›Full record

ArticleThe Yale journal of biology and medicine2024

Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal Extracts in an

Mattia Tinazzi, Andrea Sacilotto, Veronica Cocetta, Isabella Giacomini, Floriana Raso, Giorgia Bulferi, Heide De Togni, Roberta Lanza, Pierluigi Consolo, Massimiliano Berretta and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in The Yale journal of biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07475299 (The Impact of a Synbiotic Supplement Containing Botanical Extracts and Multiple Probiotic Strains on Gut Microbiota Balance in Patients With Irritable Bowel Syndrome), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07475299 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Impact of a Synbiotic Supplement Containing Botanical Extracts and Multiple Probiotic Strains on Gut Microbiota Balance in Patients With Irritable Bowel Syndrome: A Pilot Prospective Interventional Study

TypeinterventionalSponsorIuliu Hatieganu University of Medicine and PharmacyRan2026 to 2027Enrolled8ConditionsIrritable Bowel Syndrome (IBS)ArmsSynbiotic supplement containing probiotic strains, botanical extracts, magnesium, vitamin B1, and L-theanine designed to support gut microbiota balance.
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Oxidative Stress by HAntioxidants (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mattia TinazziDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padua, Italy.
Andrea SacilottoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padua, Italy.
Veronica CocettaDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padua, Italy.
Isabella GiacominiDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padua, Italy.
Floriana RasoSchwabe Pharma Italia Srl, Egna (BZ), Italy.
Giorgia BulferiSchwabe Pharma Italia Srl, Egna (BZ), Italy.
Heide De TogniSchwabe Pharma Italia Srl, Egna (BZ), Italy.
Roberta LanzaSchwabe Pharma Italia Srl, Egna (BZ), Italy.
Pierluigi ConsoloDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Massimiliano BerrettaDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Monica MontopoliDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota is a very important factor in the state of health of an individual, its alteration implies a situation of "dysbiosis," which can be connected to functional gastrointestinal disorders and pathological conditions, such as Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), Ulcerative Colitis (UC) and Crohn's Disease (CD), and Colorectal Cancer (CRC). In this work, we studied the effect of a food supplement called ENTERO-AD containing a mix of probiotics (

Indexed as

Dietary SupplementsIntestinal MucosaPlant ExtractsProbioticsCaco-2 CellsCell SurvivalHumansInflammationInflammatory Bowel DiseasesVitaminsPlant ExtractsVitaminsCaco-2Intestinal inflammationprobioticsTEER

Identifiers

PMID39351327
PMCPMC11426300

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.