Evidence map›Paper›PMID 39351233›Full record

ArticleFrontiers in immunology2024

Varicella-zoster virus recapitulates its immune evasive behaviour in matured hiPSC-derived neurospheroids.

Jonas Govaerts, Elise Van Breedam, Sarah De Beuckeleer, Charlotte Goethals, Claudio Peter D'Incal, Julia Di Stefano, Siebe Van Calster, Tamariche Buyle-Huybrecht, Marlies Boeren, Hans De Reu and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Varicella zoster virus and the central nervous system.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Review
  4. Biological relevance ofMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jonas GovaertsLaboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.
Elise Van BreedamLaboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.
Sarah De BeuckeleerLaboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.
Charlotte GoethalsLaboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.
Claudio Peter D'IncalCell Death Signaling - Epigenetics Lab, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Julia Di StefanoLaboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.
Siebe Van CalsterLaboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.
Tamariche Buyle-HuybrechtLaboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.
Marlies BoerenLaboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.
Hans De ReuLaboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.
Søren R PaludanDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Marc ThiryLaboratory of Cell and Tissue Biology, GIGA-Neurosciences, Cell Biology L3, University of Liège, Liege, Belgium.
Marielle LebrunLaboratory of Virology and Immunology, GIGA-Infection, Inflammation and Immunity, University of Liège, Liège, Belgium.
Catherine Sadzot-DelvauxLaboratory of Virology and Immunology, GIGA-Infection, Inflammation and Immunity, University of Liège, Liège, Belgium.
Helena MotalnDepartment of Biotechnology, Jozef Stefan Institute, Ljubljana, Slovenia.
Boris RogeljDepartment of Biotechnology, Jozef Stefan Institute, Ljubljana, Slovenia.
Johan Van WeyenberghDepartment of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, KU Leuven, Leuven, Belgium.
Winnok H De VosLaboratory of Cell Biology and Histology, Antwerp Center for Advanced Microscopy, Department of Veterinary Sciences, University of Antwerp, Wilrijk, Belgium.
Wim Vanden BergheCell Death Signaling - Epigenetics Lab, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Benson OgunjimiAntwerp Center for Translational Immunology and Virology (ACTIV), Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.
Peter DelputteLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.
Peter PonsaertsLaboratory of Experimental Hematology (LEH), Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicella-zoster virus (VZV) encephalitis and meningitis are potential central nervous system (CNS) complications following primary VZV infection or reactivation. With Type-I interferon (IFN) signalling being an important first line cellular defence mechanism against VZV infection by the peripheral tissues, we here investigated the triggering of innate immune responses in a human neural-like environment. For this, we established and characterised 5-month matured hiPSC-derived neurospheroids (NSPHs) containing neurons and astrocytes. Subsequently, NSPHs were infected with reporter strains of VZV (VZV

Indexed as

Herpesvirus 3, HumanInduced Pluripotent Stem CellsAstrocytesCells, CulturedCytokinesHumansImmune EvasionImmunity, InnateInterferon Type INeuronsSignal TransductionVaricella Zoster Virus InfectionCytokinesInterferon Type Iantigen presentationhuman iPScneurospheroidsstress granulesstructural integritytype-I interferon signallingvaricella-zoster virus

Identifiers

PMID39351233
PMCPMC11439716

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.