Evidence map›Paper›PMID 39351197›Full record

ArticleiScience2024

Quiescence and aging of melanocyte stem cells and a novel association with programmed death-ligand 1.

Joseph W Palmer, Kyrene M Villavicencio, Misgana Idris, Ian J Baranyk, Nunaya Polycarp, Alex D Dawson, Dominique Weddle, NISC Comparative Sequencing Program, William J Pavan, Fabian V Filipp and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joseph W PalmerDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Kyrene M VillavicencioDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Misgana IdrisDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Ian J BaranykDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Nunaya PolycarpDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Alex D DawsonDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Dominique WeddleDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
NISC Comparative Sequencing Program
William J PavanGenetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Fabian V FilippCancer Systems Biology, Institute of Diabetes and Cancer, Helmholtz Zentrum München, Ingolstädter Landstraβe 1, 85764 München, Germany.
Melissa L HarrisDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5M
Building an in-vivo gene regulatory network for melanocyte stem cell maintenance.R00AG047128 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HARRIS, MELISSA L · 2016 to 2018
$745k
Tumor pyruvate kinase as key regulator of cancer metabolismR00CA154887 · NCI · UNIVERSITY OF CALIFORNIA, MERCED · PI FILIPP, FABIAN VOLKER · 2012 to 2014
$725k
Tumor pyruvate kinase as key regulator of cancer metabolismK99CA154887 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI FILIPP, FABIAN VOLKER · 2011 to 2012
$177k
NCI NIH HHS K99 CA154887NCI NIH HHS R00 CA154887NIAID NIH HHS P01 AI056299NIA NIH HHS R00 AG047128
6 · The paper itself

Abstract

Cellular quiescence is a reversible and tightly regulated stem cell function essential for healthy aging. However, the elements that control quiescence during aging remain poorly defined. Using melanocyte stem cells (McSCs), we find that stem cell quiescence is neither passive nor static. For example, gene expression profiling of the transition from proliferating melanoblasts to quiescent melanocyte stem cells reveals tissue-specific regulation of the immune checkpoint protein PD-L1.

Indexed as

Functional aspects of cell biologyStem cells research

Identifiers

PMID39351197
PMCPMC11440800

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.