ArticleBiomaterials translational2024
Electrical stimulation with polypyrrole-coated polycaprolactone/silk fibroin scaffold promotes sacral nerve regeneration by modulating macrophage polarisation.
Article in Biomaterials translational, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Salidroside-loaded stem cell-derived artificial nanovesicles in hydrogel microneedles alleviate inflammation and enhance diabetic wound regeneration.Materials today. Bio · 2026Article
- Challenges and prospects of polymeric biomaterials in immune engineering: A review.Journal of biomaterials applications · 2026Review
- Multifunctional conductive dressings for wound healing support.Chemical science · 2026Review
- Harnessing piezoelectric stimulation to modulate PI3K-AKT signaling for intervertebral disc regeneration.Bioactive materials · 2026Article
- Exercise-mimetic electrical stimulation of muscles triggered by sonopiezoelectric therapy promotes functional repair of abdominal wall defects.Materials today. Bio · 2026Article
- Structural Features of Nerve Guidance Conduits and Scaffolds in Preventing Axonal Misdirection: A Systematic Review of Retrograde Tracing Studies.Bioengineering (Basel, Switzerland) · 2026Review
- 3D Bioprinted Neural Tissues: Emerging Strategies for Regeneration and Disease Modeling.Pharmaceutics · 2025Review
- PTEN as a prognostic factor for radiotherapy plus immunotherapy response in nasopharyngeal carcinoma.Journal of nanobiotechnology · 2025Article
- Immunomodulatory biomaterials for vascularized and innervated skeletal muscle repair.Frontiers in immunology · 2025Review
- Physical cues in biomaterials modulate macrophage polarization for bone regeneration: a review.Frontiers in bioengineering and biotechnology · 2025Review
- Research progress on composite nerve guidance conduits with immune-regulatory functions.Frontiers in immunology · 2025Review
- Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair.Frontiers in cell and developmental biology · 2024Review
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral nerve injury poses a great threat to neurosurgery and limits the regenerative potential of sacral nerves in the neurogenic bladder. It remains unknown whether electrical stimulation can facilitate sacral nerve regeneration in addition to modulate bladder function. The objective of this study was to utilise electrical stimulation in sacra nerve crush injury with newly constructed electroconductive scaffold and explore the role of macrophages in electrical stimulation with crushed nerves. As a result, we generated a polypyrrole-coated polycaprolactone/silk fibroin scaffold through which we applied electrical stimulation. The electrical stimulation boosted nerve regeneration and polarised the macrophages towards the M2 phenotype. An in vitro test using bone marrow derived macrophages revealed that the pro-regenerative polarisation of M2 were significantly enhanced by electrical stimulation. Bioinformatics analysis showed that the expression of signal transducer and activator of transcriptions (STATs) was differentially regulated in a way that promoted M2-related genes expression. Our work indicated the feasibility of electricals stimulation used for sacral nerve regeneration and provided a firm demonstration of a pivotal role which macrophages played in electrical stimulation.
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