Evidence map›Paper›PMID 39351151›Full record

ArticleFrontiers in veterinary science2024

RBC-hitchhiking PLGA nanoparticles loading β-glucan as a delivery system to enhance

Sheng Li, Yao Wang, Qianqian Liu, Feng Tang, Xinnan Zhang, Shuyao Yang, Qiran Wang, Qian Yang, Shanshan Li, Jie Liu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sheng LiCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.
Yao WangCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.
Qianqian LiuCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.
Feng TangCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.
Xinnan ZhangCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.
Shuyao YangCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.
Qiran WangCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.
Qian YangCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.
Shanshan LiInstitute of Qinghai-Tibetan Plateau, Southwest Minzu University, Chengdu, Sichuan, China.
Jie LiuCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.
Lu HanInstitute of Qinghai-Tibetan Plateau, Southwest Minzu University, Chengdu, Sichuan, China.
Yi LiaoCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.
Xuemei YinCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.
Jing FanCollege of Pharmacy, Chengdu University, Chengdu, China.
Haibo FengCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Red blood cells (RBCs) naturally trap some bacterial pathogens in the circulation and kill them by oxidative stress. Following neutralization, the bacteria are presented to antigen-presenting cells in the spleen by the RBCs. This ability of RBCs has been harnessed to develop a system where they play a crucial role in enhancing the immune response, offering a novel approach to enhance the body's immunity. In this work, a conjugate, G-OVA, was formed by connecting β-glucan and OVA through a disulfide bond. Poly (lactic-co-glycolic acid) (PLGA) was then employed to encapsulate G-OVA, yielding G-OVA-PLGA. Finally, the nanoparticles were adsorbed onto RBCs to develop G-OVA-PLGA@RBC. The results demonstrated that the delivery of nanoparticles by RBCs enhanced the antibody response to antigens both

Indexed as

immunizationnanoparticlepolysaccharideRBC-hitchhikingβ-glucan

Identifiers

PMID39351151
PMCPMC11439874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.