Evidence map›Paper›PMID 39351074›Full record

ArticleMolecular therapy. Oncology2024

The therapeutic effect of DX2 inhibition in nicotine-induced lung cancer progression.

Soyoung Park, Ah-Young Oh, Byung-Su Hong, Yun-Jeong Shin, Hyewon Jang, Hyunghwan Seo, So-Mi Kang, Tae-Gyun Woo, Hyo-Pin Park, Jiwon Jeong and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Soyoung ParkDepartment of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Republic of Korea.
Ah-Young OhDepartment of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Republic of Korea.
Byung-Su HongDepartment of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Republic of Korea.
Yun-Jeong ShinDepartment of Agricultural Biotechnology, College of Agricultural Science, Seoul National University, Seoul 08826, Republic of Korea.
Hyewon JangDepartment of Agricultural Biotechnology, College of Agricultural Science, Seoul National University, Seoul 08826, Republic of Korea.
Hyunghwan SeoDepartment of Agricultural Biotechnology, College of Agricultural Science, Seoul National University, Seoul 08826, Republic of Korea.
So-Mi KangDepartment of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Republic of Korea.
Tae-Gyun WooDepartment of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Republic of Korea.
Hyo-Pin ParkDepartment of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Republic of Korea.
Jiwon JeongDepartment of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Republic of Korea.
Hye-Ju KimDepartment of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Republic of Korea.
Bae-Hoon KimDepartment of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Republic of Korea.
Yonghoon KwonDepartment of Agricultural Biotechnology, College of Agricultural Science, Seoul National University, Seoul 08826, Republic of Korea.
Bum-Joon ParkDepartment of Molecular Biology, College of Natural Science, Pusan National University, Busan 46241, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative splicing products of AIMP2 and AIMP2-DX2 (DX2) have been reported to be associated with human lung cancer. In fact, DX2 expression is elevated in human lung cancers, and DX2 transgenic mice also develop lung cancer, in particular small cell lung cancer (SCLC). However, the mechanism by which DX2 is induced during cancer progression has not been clearly elucidated. Here, we show that DX2 is induced by nicotine, the main component of smoking-related chemicals, which can stabilize the human epidermal growth factor receptor 2 (HER2) protein and transcriptionally increase sonic hedgehog (Shh). Indeed, nicotine showed tumorigenicity via DX2 by promoting spheroid formation and

Indexed as

anti-cancer drugsDX2HER2lung cancernicotineoncogenesissmall cell lung cancersmall-molecule drugssmokingSonic hedgehog

Identifiers

PMID39351074
PMCPMC11439892

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.