Evidence map›Paper›PMID 39350981›Full record

ReviewWorld journal of gastrointestinal oncology2024

Matching traditional Chinese medicine and western medicine-based research: Advanced nutraceutical development for proactive gastric cancer prevention.

Matteo Micucci, Bian-Zhao Xiang, Chen-Min Ting, Hiu-Yee Kwan, Michele Mari, Michele Retini, Sabrina Burattini, Riham Osman, Udodinma Jude Okeke, Fuad Othman Abdullah and 2 more

Abstract readReview
In one paragraph

Review in World journal of gastrointestinal oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matteo MicucciDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino 61029, Italy. matteo.micucci@uniurb.it.
Bian-Zhao XiangHong Kong Chinese Medicine Clinical Study Centre, Chinese EQUATOR Centre, School of Chinese Medicine, Chinese Clinical Trial Registry (Hong Kong), Hong Kong Baptist University, Hong Kong 999077, China.
Chen-Min TingCentre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China.
Hiu-Yee KwanCentre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China.
Michele MariDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino 61029, Italy.
Michele RetiniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino 61029, Italy.
Sabrina BurattiniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino 61029, Italy.
Riham OsmanDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino 61029, Italy.
Udodinma Jude OkekeDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino 61029, Italy.
Fuad Othman AbdullahDepartment of Chemistry, College of Science, Salahaddin University-Erbil, Erbil 44001, Iraq.
Federico GianfantiInstitute of Oncology Research, Bellinzona CH6500, Switzerland.
Michela BattistelliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino 61029, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC), the third leading cause of cancer-related death globally, is complex and heterogeneous. This review explores multidisciplinary investigations of traditional Chinese medicine (TCM) combined with Western medical practices, emphasizing the development of nutraceuticals for cancer prevention. Using advanced analytical chemistry and food chemistry techniques, this study investigated how TCM components may be optimized for nutraceutical development. Focusing on molecular interactions with GC pathways, particularly the NF-κB, PI3K/Akt, and Wnt/β-catenin pathways, we examined the effects of TCM polyherbal formulas, extracts, and isolated compounds. These agents modulate apoptosis and cellular proliferation, underscoring their potential in preventive strategies. The convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health framework. This approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease prevention. The combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.

Indexed as

Food chemistryGastric cancerMolecular networkNutraceuticalsPhytochemistryPrecision medicineTraditional Chinese medicine

Identifiers

PMID39350981
PMCPMC11438774

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.