Evidence map›Paper›PMID 39350930›Full record

ArticleJournal of pharmacopuncture2024

In Vitro Antioxidant Activity and Anticonvulsant Properties on Zebrafish PTZ-Induced Seizure Model of a

Elina Malén Saint Martin, Ayelen Morena Sosa, Carolina Soledad Martinez, Jimena Prieto, Carla Marrassini, Cecilia Beatriz Dobrecky, María Rosario Alonso, Claudia Anesini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmacopuncture, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elina Malén Saint MartinPharmacognosy Unit, Department of Pharmacology, Faculty of Pharmacy and Biochemistry, Institute of Chemistry and Drug Metabolism (IQUIMEFA UBA CONICET), University of Buenos Aires, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-5784-5894
Ayelen Morena SosaBio-nanotechnology Laboratory, Department of Technology and Science, National University of Quilmes (GBEyB, IMBICE-CONICET-CICPBA), Bernal, Argentina.ORCID https://orcid.org/0000-0002-5028-0384
Carolina Soledad MartinezBio-nanotechnology Laboratory, Department of Technology and Science, National University of Quilmes (GBEyB, IMBICE-CONICET-CICPBA), Bernal, Argentina.ORCID https://orcid.org/0000-0001-6649-4523
Jimena PrietoBio-nanotechnology Laboratory, Department of Technology and Science, National University of Quilmes (GBEyB, IMBICE-CONICET-CICPBA), Bernal, Argentina.ORCID https://orcid.org/0000-0003-1111-1200
Carla MarrassiniPharmacognosy Unit, Department of Pharmacology, Faculty of Pharmacy and Biochemistry, Institute of Chemistry and Drug Metabolism (IQUIMEFA UBA CONICET), University of Buenos Aires, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-1237-1330
Cecilia Beatriz DobreckyPharmacobotany Unit, Department of Pharmacology and Pharmaceutical Technology I Unit, Pharmaceutical and Technology Department (InTecFyB), Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-6575-0246
María Rosario AlonsoPharmacognosy Unit, Department of Pharmacology, Faculty of Pharmacy and Biochemistry, Institute of Chemistry and Drug Metabolism (IQUIMEFA UBA CONICET), University of Buenos Aires, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-6041-7153
Claudia AnesiniPharmacognosy Unit, Department of Pharmacology, Faculty of Pharmacy and Biochemistry, Institute of Chemistry and Drug Metabolism (IQUIMEFA UBA CONICET), University of Buenos Aires, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-7338-9761

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Methods: Study of the constituents of TE, TE's antioxidant and anticonvulsant activities and toxicity, and analysis of the possible relation between the potential activities and the compounds present in the extract. In order to demonstrate TE's anticonvulsant activity a zebrafish model was used. The study also assessed TE's toxicity and antioxidant activity. To standardize the extract, total polyphenols and flavonoids were quantified and specific flavonoids were identified and quantified using HPLC-MS/MS and HPLC-UV. Results: TE exhibited anticonvulsant activity at low concentrations and demonstrated antioxidant effects by scavenging free radicals, exhibiting superoxide dismutase and peroxidase-like activities, as well as inhibiting lipoperoxidation. These actions can be attributed to the presence of polyphenols, particularly flavonoids. Conclusion: TE holds promise as a complementary herbal medicine in the treatment of epilepsy and may also offer benefits for other neuropathies associated with oxidative stress, such as Parkinson's disease and Alzheimer's disease.

Indexed as

epilepsyflavonoidsinfusionnatural products

Identifiers

PMID39350930
PMCPMC11439512

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.